Linked Life Data

18562401

Source:http://linkedlifedata.com/resource/pubmed/id/18562401

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-7-23
pubmed:abstractText
Tardive dyskinesia (TD) is associated with polymorphisms of the dopamine D(3), serotonin 2A and 2C receptors (DRD3, HTR2A and HTR2C, respectively). This study investigated the possible relationship between TD and the polymorphisms Ser9Gly (DRD3), 102T>C (HTR2A), -1438G>A(HTR2A) and Cys23Ser (HTR2C) in African-Caribbean inpatients. One hundred and twenty-six patients under chronic antipsychotic treatment were genotyped. The assessment of TD was carried out with the abnormal involuntary movement scale (AIMS). The relationships between the carriership of the least frequent alleles and the respective orofaciolingual dyskinesia (TDof) (sum of the items 1-4 of the AIMS), limb-truncal dyskinesia (TDlt) (sum of items 5-7 of the AIMS) and TD (sum of items 1-7 of the AIMS) were analyzed with ANCOVA, comparing means with age as a covariate and stratification for carriers and non-carriers of the mutations. In addition, we conducted pre-planned t-tests to compare AIMS values of carriers of the combinations of alleles versus the corresponding non-carriers. In the study population, females with 9Ser carriership exhibited higher AIMS values than non-carriers. Male subjects with 9Ser carriership in combination with 23Ser or -1438A carriership exhibited higher AIMS values. In male patients also, the combination of 23Ser and -1438A carriership increased TD. The study clearly shows that the African-Caribbean population differs from the Caucasian population with regard to the association of TD with the polymorphisms studied and suggests that the association of TD with the studied polymorphisms of the 5-HT(2C) and probably of the 5-HT(2A) receptor are the result of a changed susceptibility of the patients, independent of the action of the antipsychotics on these receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0269-8811
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
652-9
pubmed:meshHeading
pubmed-meshheading:18562401-Adult, pubmed-meshheading:18562401-African Continental Ancestry Group, pubmed-meshheading:18562401-Aged, pubmed-meshheading:18562401-Aging, pubmed-meshheading:18562401-Alleles, pubmed-meshheading:18562401-Antipsychotic Agents, pubmed-meshheading:18562401-DNA, pubmed-meshheading:18562401-Dyskinesia, Drug-Induced, pubmed-meshheading:18562401-Female, pubmed-meshheading:18562401-Gene Frequency, pubmed-meshheading:18562401-Genetic Variation, pubmed-meshheading:18562401-Genotype, pubmed-meshheading:18562401-Heterozygote, pubmed-meshheading:18562401-Humans, pubmed-meshheading:18562401-Male, pubmed-meshheading:18562401-Middle Aged, pubmed-meshheading:18562401-Netherlands Antilles, pubmed-meshheading:18562401-Receptor, Serotonin, 5-HT2A, pubmed-meshheading:18562401-Receptor, Serotonin, 5-HT2C, pubmed-meshheading:18562401-Receptors, Dopamine D3
pubmed:year
2009
pubmed:articleTitle
The role of dopamine D3, 5-HT2A and 5-HT2C receptor variants as pharmacogenetic determinants in tardive dyskinesia in African-Caribbean patients under chronic antipsychotic treatment: Curacao extrapyramidal syndromes study IX.
pubmed:affiliation
Department of Pharmacotherapy and Pharmaceutical Care, University of Groningen, Groningen, The Netherlands. B.Wilffert@ZNB.NL
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't