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pubmed-article:18552145pubmed:abstractTextTumor uptake of copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone) (copper-ATSM), a hypoxia-targeting radiopharmaceutical, assessed by PET has been found to correlate with prognosis in several human cancers. Wide clinical utility of this tracer will require its labeling with a copper radionuclide having a longer half-life than the (60)Cu used in studies to date. The purpose of this work was to obtain the requisite preclinical data for copper-ATSM to file an investigational new drug application, followed by a crossover comparison of PET image quality and tumor uptake with (60)Cu-ATSM and (64)Cu-ATSM in women with cancer of the uterine cervix.lld:pubmed
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pubmed-article:18552145pubmed:articleTitleAn imaging comparison of 64Cu-ATSM and 60Cu-ATSM in cancer of the uterine cervix.lld:pubmed
pubmed-article:18552145pubmed:affiliationDivision of Radiological Sciences, Mallinckrodt Institute of Radiology, St. Louis, Missouri, USA. lewisj2@mskcc.orglld:pubmed
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