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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2008-12-16
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pubmed:abstractText |
The translocator protein (TSPO; 18 kDa), the new name of the peripheral-type benzodiazepine receptor, is localised in mitochondria of glial cells and expressed in very low concentrations in normal brain. Their expression rises after microglial activation following brain injury. Accordingly, TSPO are potential targets to evaluate neuroinflammatory changes in a variety of CNS disorders.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1619-7089
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2203-11
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pubmed:meshHeading |
pubmed-meshheading:18536913-Animals,
pubmed-meshheading:18536913-Autoradiography,
pubmed-meshheading:18536913-Bicyclo Compounds, Heterocyclic,
pubmed-meshheading:18536913-Brain,
pubmed-meshheading:18536913-Disease Models, Animal,
pubmed-meshheading:18536913-Immunohistochemistry,
pubmed-meshheading:18536913-Inflammation,
pubmed-meshheading:18536913-Isoquinolines,
pubmed-meshheading:18536913-Male,
pubmed-meshheading:18536913-Microglia,
pubmed-meshheading:18536913-Rats,
pubmed-meshheading:18536913-Receptors, GABA,
pubmed-meshheading:18536913-Tissue Distribution,
pubmed-meshheading:18536913-Tomography, Emission-Computed, Single-Photon
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pubmed:year |
2008
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pubmed:articleTitle |
Evaluation of CLINDE as potent translocator protein (18 kDa) SPECT radiotracer reflecting the degree of neuroinflammation in a rat model of microglial activation.
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pubmed:affiliation |
Inserm, U930, Tours 37000, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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