Linked Life Data

18520992

Source:http://linkedlifedata.com/resource/pubmed/id/18520992

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2008-6-3
pubmed:abstractText
We examined the effects of chronic morphine treatment and withdrawal on the expression of metabotropic glutamate (mGlu)1, mGlu5, and mGlu2/3 receptors in the nucleus accumbens and caudate putamen. Rats received a 14-day morphine treatment (escalating doses from 10 to 140 mg/kg). Receptor density was evaluated after chronic treatment and after 1, 3, and 14 days of withdrawal. mGlu1 and mGlu5 expression in the nucleus accumbens and in the caudate putamen was not affected by any of the experimental manipulations. In contrast, mGlu2/3 receptors in the nucleus accumbens, but not in the caudate putamen, increased at day 1, 3, and 14 of withdrawal. We suggest that an increased expression of mGlu2/3 receptors in the nucleus accumbens might contribute to the symptoms of morphine withdrawal.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
911-4
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Morphine withdrawal increases metabotropic glutamate 2/3 receptors expression in nucleus accumbens.
pubmed:affiliation
Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy.
pubmed:publicationType
Journal Article