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rdf:type |
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lifeskim:mentions |
umls-concept:C0018787,
umls-concept:C0032659,
umls-concept:C0079399,
umls-concept:C0085862,
umls-concept:C0205214,
umls-concept:C0205419,
umls-concept:C0237401,
umls-concept:C0314603,
umls-concept:C1280500,
umls-concept:C1299583,
umls-concept:C1417759,
umls-concept:C1549571,
umls-concept:C1608386,
umls-concept:C1704735,
umls-concept:C1826455
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pubmed:issue |
5
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pubmed:dateCreated |
2008-10-3
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pubmed:abstractText |
A longer heart-rate corrected QT interval (QTc) is associated with increased risk of ventricular arrhythmias. Women have longer resting QTc and are more likely than men to develop drug-induced QT prolongation. Recent studies have shown association between resting QTc and a common variant (rs10494366) of the NOS1 regulator, NOS1AP. We investigated the association between rs10494366 in NOS1AP and QTc, and assessed gender-specific NOS1AP associations with QTc during rest and after exercise.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1464-3685
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pubmed:author |
pubmed-author:BraundPeterP,
pubmed-author:BurtonPaul RPR,
pubmed-author:HajatCotherC,
pubmed-author:KähönenMikaM,
pubmed-author:LehtimäkiTerhoT,
pubmed-author:LehtinenRamiR,
pubmed-author:MacfarlanePeter WPW,
pubmed-author:NgG AndreGA,
pubmed-author:NieminenTuomoT,
pubmed-author:SamaniNilesh JNJ,
pubmed-author:TobinMartin DMD,
pubmed-author:TomaszewskiMaciejM,
pubmed-author:ViikJariJ
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pubmed:issnType |
Electronic
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1132-41
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18511491-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:18511491-Adult,
pubmed-meshheading:18511491-Alleles,
pubmed-meshheading:18511491-Electrocardiography,
pubmed-meshheading:18511491-Exercise,
pubmed-meshheading:18511491-Female,
pubmed-meshheading:18511491-Finland,
pubmed-meshheading:18511491-Genetic Variation,
pubmed-meshheading:18511491-Genotype,
pubmed-meshheading:18511491-Great Britain,
pubmed-meshheading:18511491-Health Surveys,
pubmed-meshheading:18511491-Heart,
pubmed-meshheading:18511491-Heart Rate,
pubmed-meshheading:18511491-Humans,
pubmed-meshheading:18511491-Linear Models,
pubmed-meshheading:18511491-Long QT Syndrome,
pubmed-meshheading:18511491-Male,
pubmed-meshheading:18511491-Middle Aged,
pubmed-meshheading:18511491-Sex Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations.
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pubmed:affiliation |
Department of Health Sciences, University of Leicester, UK. mt47@leicester.ac.uk
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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