| pubmed-article:1850367 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1850367 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:1850367 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1850367 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:1850367 | lifeskim:mentions | umls-concept:C0029045 | lld:lifeskim |
| pubmed-article:1850367 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:1850367 | lifeskim:mentions | umls-concept:C0031686 | lld:lifeskim |
| pubmed-article:1850367 | lifeskim:mentions | umls-concept:C0069389 | lld:lifeskim |
| pubmed-article:1850367 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1850367 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:1850367 | lifeskim:mentions | umls-concept:C1523105 | lld:lifeskim |
| pubmed-article:1850367 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1850367 | pubmed:dateCreated | 1991-5-24 | lld:pubmed |
| pubmed-article:1850367 | pubmed:abstractText | Treatment of one-cell mouse embryos with okadaic acid (OA), which is an inhibitor of protein phosphatases 1 and 2A, induces a concentration-dependent precocious nuclear envelope breakdown (NEBD) of the pronuclei; at 10 microM okadaic acid, NEBD starts to occur after 1 hr and the embryos become committed to NEBD after about 45 min. Correlated with NEBD is the conversion of a protein of Mr 32,000 (p32) to more highly phosphorylated forms. One-cell embryos cultured continuously in OA-containing medium do not cleave, whereas one-cell embryos incubated for 15-60 min prior to transfer to OA-free medium reveal a time-dependent inhibition in their ability to cleave. OA treatment of oocytes that are arrested from resuming spontaneous maturation by either a phosphodiesterase inhibitor or biologically active phorbol diester results in germinal vesicle breakdown and the maturation-associated changes in the pattern of protein phosphorylation, which include the apparent phosphorylation of p32. Results of these experiments implicate protein phosphatases in the G2 to M transition of the cell cycle in both meiotic and mitotic cells. | lld:pubmed |
| pubmed-article:1850367 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1850367 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1850367 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1850367 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1850367 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1850367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1850367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1850367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1850367 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1850367 | pubmed:month | May | lld:pubmed |
| pubmed-article:1850367 | pubmed:issn | 0012-1606 | lld:pubmed |
| pubmed-article:1850367 | pubmed:author | pubmed-author:SchultzR MRM | lld:pubmed |
| pubmed-article:1850367 | pubmed:author | pubmed-author:SchwartzD ADA | lld:pubmed |
| pubmed-article:1850367 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1850367 | pubmed:volume | 145 | lld:pubmed |
| pubmed-article:1850367 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1850367 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1850367 | pubmed:pagination | 119-27 | lld:pubmed |
| pubmed-article:1850367 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:1850367 | pubmed:meshHeading | pubmed-meshheading:1850367-... | lld:pubmed |
| pubmed-article:1850367 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1850367 | pubmed:articleTitle | Stimulatory effect of okadaic acid, an inhibitor of protein phosphatases, on nuclear envelope breakdown and protein phosphorylation in mouse oocytes and one-cell embryos. | lld:pubmed |
| pubmed-article:1850367 | pubmed:affiliation | Department of Biology, University of Pennsylvania, Philadelphia 19104-6018. | lld:pubmed |
| pubmed-article:1850367 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1850367 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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