18501656

Source:http://linkedlifedata.com/resource/pubmed/id/18501656

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0002895, umls-concept:C0209606
pubmed:issue	1-2
pubmed:dateCreated	2008-6-18
pubmed:abstractText	The alpha4beta1 integrin is an adhesion receptor expressed on reticulocytes in sickle cell disease (SCD) and mediates the adhesion of these cells to sub-endothelial matrix proteins and the endothelium. In this review, we describe the mechanism of activation of the alpha4beta1 integrin on sickle reticulocytes and discuss novel roles for this integrin in SCD as a result of this activation. We also illustrate novel therapies in SCD that may target the integrin and alleviate vaso-occlusion.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9423846
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Integrin alpha4beta1
pubmed:status	MEDLINE
pubmed:issn	1246-7820
pubmed:author	pubmed-author:BrittainJ EJE, pubmed-author:PariseL VLV
pubmed:issnType	Print
pubmed:volume	15
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	19-22
pubmed:meshHeading	pubmed-meshheading:18501656-Anemia, Sickle Cell, pubmed-meshheading:18501656-Humans, pubmed-meshheading:18501656-Integrin alpha4beta1, pubmed-meshheading:18501656-Reticulocytes
pubmed:articleTitle	The alpha4beta1 integrin in sickle cell disease.
pubmed:affiliation	Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, CB 7260, Chapel Hill, NC 27599, USA.
pubmed:publicationType	Journal Article, Review