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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2008-6-5
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pubmed:abstractText |
We synthesized and evaluated various [2-(4-quinolyloxy)phenyl]methanone derivatives. These compounds had novel chemical structures that were distinct from those of previously reported inhibitors. Biological data suggested that these compounds inhibited transforming growth factor-beta signaling by interacting with the ATP-binding pocket of the transforming growth factor-beta type I receptor kinase domain. Here, we report on the synthesis and structure-activity relationships of the compounds in this series.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3326-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18479116-Activin Receptors, Type I,
pubmed-meshheading:18479116-Cell Line, Tumor,
pubmed-meshheading:18479116-Genes, Reporter,
pubmed-meshheading:18479116-Humans,
pubmed-meshheading:18479116-Luciferases,
pubmed-meshheading:18479116-Phosphorylation,
pubmed-meshheading:18479116-Quinolines,
pubmed-meshheading:18479116-Smad2 Protein,
pubmed-meshheading:18479116-Smad3 Protein,
pubmed-meshheading:18479116-Structure-Activity Relationship,
pubmed-meshheading:18479116-Transforming Growth Factor beta
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pubmed:year |
2008
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pubmed:articleTitle |
Synthesis and evaluation of [2-(4-quinolyloxy)phenyl]methanone derivatives: novel selective inhibitors of transforming growth factor-beta kinase.
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pubmed:affiliation |
KIRIN Pharma Co Ltd, Shibuya, Tokyo, Japan. tshimizu@kirin.co.jp
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pubmed:publicationType |
Journal Article
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