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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1991-3-15
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pubmed:abstractText |
Evidence at the molecular level is presented in support of alkylation of O6-guanine moieties of DNA as the mechanism of cytotoxicity of Clomesone to HT-29 cells and consists in the isolation and identification of a product resulting from alkylation of calf thymus DNA with Clomesone, followed by depurination to yield 7-(2-hydroxyethyl)guanine, whose formation is reasonably explained by O6-guanine chloroethylation followed by intramolecular alkylation at N7 of guanine and subsequent hydrolysis to the hydroxyethylguanine.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-2952
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
457-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1847287-Alkylation,
pubmed-meshheading:1847287-Animals,
pubmed-meshheading:1847287-Antineoplastic Agents,
pubmed-meshheading:1847287-Cattle,
pubmed-meshheading:1847287-Chromatography, High Pressure Liquid,
pubmed-meshheading:1847287-DNA,
pubmed-meshheading:1847287-Guanine,
pubmed-meshheading:1847287-Hydrolysis,
pubmed-meshheading:1847287-Mesylates,
pubmed-meshheading:1847287-Methylation,
pubmed-meshheading:1847287-Thymus Gland
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pubmed:year |
1991
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pubmed:articleTitle |
Identification of 7-(2-hydroxyethyl)guanine as a product of alkylation of calf thymus DNA with clomesone.
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pubmed:affiliation |
Southern Research Institute, Birmingham, AL 35255.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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