| pubmed-article:18437014 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18437014 | lifeskim:mentions | umls-concept:C0018183 | lld:lifeskim |
| pubmed-article:18437014 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:18437014 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
| pubmed-article:18437014 | lifeskim:mentions | umls-concept:C0242488 | lld:lifeskim |
| pubmed-article:18437014 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:18437014 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:18437014 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:18437014 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18437014 | pubmed:dateCreated | 2008-4-25 | lld:pubmed |
| pubmed-article:18437014 | pubmed:abstractText | Granulocyte macrophage-colony stimulating factor (GM-CSF) has immuno-stimulatory effects. We hypothesized that GM-CSF plays an important role both in lipopolysaccharide (LPS)- and hemorrhage-induced acute lung injury (ALI). We also postulated that GM-CSF augments LPS-induced inflammation by priming neutrophils. ALI was induced in GM-CSF-/- or control C57BL mice either by LPS injection or by hemorrhage. Lung inflammation (by lung expression for tumor necrosis factor-alpha (TNF-alpha), macrophage inflammatory protein-2 (MIP-2), interleukin-1beta (IL-1beta), interleukin- 6 (IL-6), and keratinocyte-derived chemokine) and lung injury (by myeloperoxidase and Evans blue dye assay) were evaluated after ALI. Incremental doses of LPS (0, 1, 10, and 100 ng/mL) and GM-CSF (0, 1, 10, and 100 ng/mL) were added to bone marrow neutrophils. The expression of TNF-alpha, MIP-2, and IL-1beta was evaluated with enzyme linked immunosorbent assay. The mRNA expression of three cytokines, and the nuclear translocation of nuclear factor kappa B (NF kappa-B) were evaluated by reverse transcriptase-polymerase chain reaction and electrophoretic mobility shift assay, respectively. GM-CSF -/- mice showed decreased neutrophil infiltration, less leakage, and lower expression of cytokines in the lung after LPS or hemorrhage. GM-CSF augmented LPS-induced protein and mRNA expression of TNF-alpha, MIP-2 and IL-1beta, which was mediated by increased intra-nuclear translocation of NF-kappaB. GM-CSF plays an important role in high-dose LPS and hemorrhage-induced ALI, which appears to be mediated by its priming effect on neutrophils. | lld:pubmed |
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| pubmed-article:18437014 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18437014 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18437014 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18437014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18437014 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18437014 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:18437014 | pubmed:issn | 1011-8934 | lld:pubmed |
| pubmed-article:18437014 | pubmed:author | pubmed-author:ChoiByoung... | lld:pubmed |
| pubmed-article:18437014 | pubmed:author | pubmed-author:JungJae WooJW | lld:pubmed |
| pubmed-article:18437014 | pubmed:author | pubmed-author:SongJu HanJH | lld:pubmed |
| pubmed-article:18437014 | pubmed:author | pubmed-author:KimJae YeolJY | lld:pubmed |
| pubmed-article:18437014 | pubmed:author | pubmed-author:ShinJong... | lld:pubmed |
| pubmed-article:18437014 | pubmed:author | pubmed-author:ParkIn WonIW | lld:pubmed |
| pubmed-article:18437014 | pubmed:author | pubmed-author:ChoiJae... | lld:pubmed |
| pubmed-article:18437014 | pubmed:author | pubmed-author:KwakHee WonHW | lld:pubmed |
| pubmed-article:18437014 | pubmed:author | pubmed-author:JeonEun JuEJ | lld:pubmed |
| pubmed-article:18437014 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18437014 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:18437014 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18437014 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18437014 | pubmed:pagination | 288-95 | lld:pubmed |
| pubmed-article:18437014 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18437014 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18437014 | pubmed:articleTitle | Granulocyte macrophage-colony stimulating factor (GM-CSF) augments acute lung injury via its neutrophil priming effects. | lld:pubmed |
| pubmed-article:18437014 | pubmed:affiliation | Department of Internal Medicine, Chung Ang University College of Medicine, 224-1 Heukseok-dong, Dongjak-gu, Seoul, Korea. | lld:pubmed |
| pubmed-article:18437014 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18437014 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12981 | entrezgene:pubmed | pubmed-article:18437014 | lld:entrezgene |
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