| pubmed-article:18386173 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18386173 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:18386173 | lifeskim:mentions | umls-concept:C1512505 | lld:lifeskim |
| pubmed-article:18386173 | lifeskim:mentions | umls-concept:C2699153 | lld:lifeskim |
| pubmed-article:18386173 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18386173 | lifeskim:mentions | umls-concept:C1418404 | lld:lifeskim |
| pubmed-article:18386173 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:18386173 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:18386173 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:18386173 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18386173 | pubmed:dateCreated | 2009-2-4 | lld:pubmed |
| pubmed-article:18386173 | pubmed:abstractText | High levels of the cyclooxygenase-2 (COX-2) protein have been associated with invasion and metastasis of breast tumors. Both prostaglandin E(2) (PGE(2)) and interleukin-8 (IL-8) have been shown to mediate the invasive activity of COX-2 in breast cancer cells. Here we expand these studies to determine how COX-2 uses PGE(2) and IL-8 to induce breast cancer cell invasion. We demonstrated that PGE(2) and IL-8 decreased the expression of the tumor suppressor protein Programmed Cell Death 4 (PDCD4). We hypothesized that suppression of PDCD4 expression is vital to the invasive activity of PGE(2) and IL-8. In MCF-7 cells overexpressing PDCD4 (MCF-7/PDCD4), PGE(2) and IL-8 failed to induce invasion, in contrast to the parental MCF-7 cells, thus indicating that PDCD4 blocks breast cancer cell invasion. MCF-7/PDCD4 cells produced higher levels of the Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) than the parental cells. Silencing TIMP-2 mRNA in MCF-7/PDCD4 cells reversed the anti-invasive effects of PDCD4, allowing PGE(2) and IL-8 to induce the invasion of these cells. Here we report the novel findings that suppression of PDCD4 expression is vital for the invasive activity of COX-2 mediated by PGE(2) and IL-8, and that PDCD4 increases TIMP-2 expression to inhibit breast cancer cell invasion. | lld:pubmed |
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| pubmed-article:18386173 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18386173 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18386173 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18386173 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18386173 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18386173 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18386173 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18386173 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18386173 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18386173 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18386173 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18386173 | pubmed:issn | 1573-7217 | lld:pubmed |
| pubmed-article:18386173 | pubmed:author | pubmed-author:ColburnNancy... | lld:pubmed |
| pubmed-article:18386173 | pubmed:author | pubmed-author:TariAna MAM | lld:pubmed |
| pubmed-article:18386173 | pubmed:author | pubmed-author:SimeoneAnn-Ma... | lld:pubmed |
| pubmed-article:18386173 | pubmed:author | pubmed-author:Nieves-Alicea... | lld:pubmed |
| pubmed-article:18386173 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18386173 | pubmed:volume | 114 | lld:pubmed |
| pubmed-article:18386173 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18386173 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18386173 | pubmed:pagination | 203-9 | lld:pubmed |
| pubmed-article:18386173 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18386173 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18386173 | pubmed:articleTitle | Programmed cell death 4 inhibits breast cancer cell invasion by increasing tissue inhibitor of metalloproteinases-2 expression. | lld:pubmed |
| pubmed-article:18386173 | pubmed:affiliation | Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Unit 422, Houston, TX 77030, USA. | lld:pubmed |
| pubmed-article:18386173 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18386173 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18386173 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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