Linked Life Data

18380345

Source:http://linkedlifedata.com/resource/pubmed/id/18380345

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-4-2
pubmed:abstractText
We review here results arising from the systematic functional analysis of Nova, a neuron-specific RNA binding protein targeted in an autoimmune neurological disorder associated with cancer. We have developed a combination of biochemical, genetic and bioinformatic methods to generate a global understanding of Nova's role as a splicing regulator. Genome-wide identification and validation of Nova target RNAs has yielded unexpected insights into the protein's mechanism of action and into the functionally coherent role of Nova in the biology of the neuronal synapse. These studies provide us with a platform for understanding the role of RNA binding proteins in tissue-specific splicing regulation and in disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
623
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
148-60
pubmed:dateRevised
2011-11-7
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Functional and mechanistic insights from genome-wide studies of splicing regulation in the brain.
pubmed:affiliation
MRC Laboratory of Molecular Biology, Cambridge, England.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural