| pubmed-article:18378322 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18378322 | lifeskim:mentions | umls-concept:C0162340 | lld:lifeskim |
| pubmed-article:18378322 | lifeskim:mentions | umls-concept:C1416390 | lld:lifeskim |
| pubmed-article:18378322 | lifeskim:mentions | umls-concept:C1426048 | lld:lifeskim |
| pubmed-article:18378322 | lifeskim:mentions | umls-concept:C0003209 | lld:lifeskim |
| pubmed-article:18378322 | lifeskim:mentions | umls-concept:C1424658 | lld:lifeskim |
| pubmed-article:18378322 | lifeskim:mentions | umls-concept:C1752924 | lld:lifeskim |
| pubmed-article:18378322 | lifeskim:mentions | umls-concept:C1515999 | lld:lifeskim |
| pubmed-article:18378322 | lifeskim:mentions | umls-concept:C0725066 | lld:lifeskim |
| pubmed-article:18378322 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:18378322 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18378322 | pubmed:dateCreated | 2008-4-8 | lld:pubmed |
| pubmed-article:18378322 | pubmed:abstractText | Initial studies on the biology of IL-27 provided evidence of a role for this cytokine in the initiation of Th1 responses; however, subsequent work using models of pathogen-induced and autoimmune inflammation have indicated that IL-27 has broad inhibitory effects on Th1, Th2 and Th17 subsets of T cells as well as the expansion of inducible regulatory T cells. While, the aim of this review is to highlight the functions of IL-27 in the context of inflammation it will also serve to elaborate on the molecular mechanisms involved in the production of this cytokine. The initial description of IL-27 indicated that classical antigen-presenting cells such as macrophages and dendritic cells produce IL-27, however, the agonists and signaling pathways involved in activating transcription of the two subunits of IL-27, p28 and EBV-induced gene 3 (EBI3) have only recently been described. | lld:pubmed |
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| pubmed-article:18378322 | pubmed:language | eng | lld:pubmed |
