Linked Life Data

18361753

Source:http://linkedlifedata.com/resource/pubmed/id/18361753

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-3-25
pubmed:abstractText
The objective of this study was to investigate the effects of S&S PWH, a proprietary herb and fiber combination (Bionutrigen Inc., Daejon, Republic of Korea), on body weight and lipid metabolism in rats fed with a high-fat diet. Three groups of male Sprague-Dawley rats were fed different diets for a 6-week period: normal control diet containing 5% (wt/wt) corn oil (NC group), high-fat diet containing 10% (wt/wt) lard plus 5% (wt/wt) corn oil (HF group), and high-fat diet supplemented with powdered 5% (wt/wt) S&S PWH (S&S PWH group). The body weights and relative weights of the epididymal and perirenal white adipose tissue were significantly lower in the S&S PWH group than in the HF group. S&S PWH supplementation significantly lowered plasma total cholesterol and triglyceride concentrations, whereas it elevated the ratio of high density lipoprotein-cholesterol/total-cholesterol and improved the atherogenic index. The accumulation of hepatic lipid droplets and the epididymal white adipocyte size were less in the S&S PWH group than in the HF group. Hepatic hydroxyl-3-methylglutaryl-coenzyme A reductase and acyl-coenzyme A:cholesterol acyltransferase activities were significantly lower, while adipocyte lipoprotein lipase activity was significantly higher, in the S&S PWH group than in the HF group. These beneficial effects may be due to the combined properties of the phenolic compounds present in high concentrations (1.89 g/100 g) in the S&S PWH. In conclusion, these results suggest that S&S PWH can be considered as an anti-obesity functional formula that is effective for suppressing body weight gain and enhancing lipid profile.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1096-620X
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-78
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:18361753-Adipocytes, pubmed-meshheading:18361753-Animals, pubmed-meshheading:18361753-Anti-Obesity Agents, pubmed-meshheading:18361753-Cholesterol, pubmed-meshheading:18361753-Cholesterol, HDL, pubmed-meshheading:18361753-Diet, pubmed-meshheading:18361753-Dietary Fats, pubmed-meshheading:18361753-Dietary Fiber, pubmed-meshheading:18361753-Epididymis, pubmed-meshheading:18361753-Hepatocytes, pubmed-meshheading:18361753-Hydroxymethylglutaryl CoA Reductases, pubmed-meshheading:18361753-Hypolipidemic Agents, pubmed-meshheading:18361753-Lipoprotein Lipase, pubmed-meshheading:18361753-Liver, pubmed-meshheading:18361753-Male, pubmed-meshheading:18361753-Phenols, pubmed-meshheading:18361753-Phytotherapy, pubmed-meshheading:18361753-Plant Preparations, pubmed-meshheading:18361753-Rats, pubmed-meshheading:18361753-Rats, Sprague-Dawley, pubmed-meshheading:18361753-Sterol O-Acyltransferase, pubmed-meshheading:18361753-Triglycerides
pubmed:year
2008
pubmed:articleTitle
Anti-obesity and hypolipidemic effects of a proprietary herb and fiber combination (S&S PWH) in rats fed high-fat diets.
pubmed:affiliation
Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't