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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2008-12-10
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pubmed:abstractText |
Epidemiological studies have suggested that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of Alzheimer's disease (AD). Several mechanisms have been proposed to explain these findings including increased shedding of the soluble ectodomain of the amyloid precursor protein (sAPP), which functions as a neurotrophic and neuroprotective factor in vitroand in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1660-2862
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2008 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-8
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pubmed:meshHeading |
pubmed-meshheading:18349521-Alkaline Phosphatase,
pubmed-meshheading:18349521-Amyloid beta-Protein Precursor,
pubmed-meshheading:18349521-Animals,
pubmed-meshheading:18349521-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:18349521-CHO Cells,
pubmed-meshheading:18349521-Cell Line,
pubmed-meshheading:18349521-Cell Line, Tumor,
pubmed-meshheading:18349521-Cricetinae,
pubmed-meshheading:18349521-Cricetulus,
pubmed-meshheading:18349521-Ibuprofen,
pubmed-meshheading:18349521-Indomethacin,
pubmed-meshheading:18349521-Kinetics,
pubmed-meshheading:18349521-Neuroblastoma,
pubmed-meshheading:18349521-PC12 Cells,
pubmed-meshheading:18349521-Rats,
pubmed-meshheading:18349521-Tetradecanoylphorbol Acetate
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pubmed:year |
2009
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pubmed:articleTitle |
Nonsteroidal anti-inflammatory drugs and ectodomain shedding of the amyloid precursor protein.
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pubmed:affiliation |
Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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