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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2008-4-25
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pubmed:abstractText |
Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease endothelial NO in human aortic endothelial cells. Here, we demonstrate that vascular endothelial arginase activity is increased in atherogenic-prone apolipoprotein E-null (ApoE(-/-)) and wild-type mice fed a high cholesterol diet. In ApoE(-/-) mice, selective arginase II inhibition or deletion of the arginase II gene (Arg II(-/-) mice) prevents high-cholesterol diet-dependent decreases in vascular NO production, decreases endothelial reactive oxygen species production, restores endothelial function, and prevents oxidized low-density lipoprotein-dependent increases in vascular stiffness. Furthermore, arginase inhibition significantly decreases plaque burden. These data indicate that arginase II plays a critical role in the pathophysiology of cholesterol-mediated endothelial dysfunction and represents a novel target for therapy in atherosclerosis.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1524-4571
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pubmed:author |
pubmed-author:AlpNicholas JNJ,
pubmed-author:BarabanEzraE,
pubmed-author:BenjoAlexandreA,
pubmed-author:BerkowitzDan EDE,
pubmed-author:CamaraAndreA,
pubmed-author:ChampionHunter CHC,
pubmed-author:ChristiansonDavid WDW,
pubmed-author:GerstenblithGaryG,
pubmed-author:GuptaGauravG,
pubmed-author:HusoDavidD,
pubmed-author:IliesMonicaM,
pubmed-author:LimHyun KyoHK,
pubmed-author:LimHyun KyungHK,
pubmed-author:NyhanDanielD,
pubmed-author:RyooSungwooS,
pubmed-author:SanthanamLakshmiL,
pubmed-author:ShoukasArtinA,
pubmed-author:SikkaGautamG,
pubmed-author:SohiJaysonJ,
pubmed-author:SoucyKevinK,
pubmed-author:TudayEricE
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pubmed:issnType |
Electronic
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pubmed:day |
25
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
923-32
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pubmed:meshHeading |
pubmed-meshheading:18309100-Animals,
pubmed-meshheading:18309100-Apolipoproteins E,
pubmed-meshheading:18309100-Arginase,
pubmed-meshheading:18309100-Atherosclerosis,
pubmed-meshheading:18309100-Cholesterol,
pubmed-meshheading:18309100-Endothelial Cells,
pubmed-meshheading:18309100-Endothelium, Vascular,
pubmed-meshheading:18309100-Mice,
pubmed-meshheading:18309100-Mice, Knockout,
pubmed-meshheading:18309100-Nitric Oxide,
pubmed-meshheading:18309100-Nitric Oxide Synthase Type III,
pubmed-meshheading:18309100-Up-Regulation,
pubmed-meshheading:18309100-Vascular Resistance
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pubmed:year |
2008
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pubmed:articleTitle |
Endothelial arginase II: a novel target for the treatment of atherosclerosis.
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pubmed:affiliation |
Department of Anesthesiology/Critical Care Medicine, the Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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