18286464

Source:http://linkedlifedata.com/resource/pubmed/id/18286464

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0033213, umls-concept:C0036341, umls-concept:C0683919, umls-concept:C1706387, umls-concept:C1706427
pubmed:issue	1
pubmed:dateCreated	2008-2-26
pubmed:abstractText	While meta-analytic techniques are routine in the synthesis of data from randomized controlled trials, there are no clear guidelines on how best to summarize frequency data such as incidence and prevalence estimates. Based on data from two recent systematic reviews of the incidence and prevalence of schizophrenia, this paper explores some of the conceptual and methodological issues related to the meta-analyses of frequency estimates in epidemiology. Because variations in the incidence and prevalence of disorders such as schizophrenia can be informative, there is a case against collapsing data into one pooled estimate. Variations in frequency estimates can be displayed graphically, or summarized with quantiles around measures of central tendency. If pooled estimated are of interest, then researchers need to be aware that studies based on large samples will leverage greater weight on the pooled value. Based on systematic reviews of the incidence and prevalence of schizophrenia, we explore if these and related issues are of practical concern. When used with appropriate caution, meta-analysis can complement the synthesis of frequency data in epidemiology; however, researchers interested in variation should not rely on meta-analysis alone.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9111433
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:issn	1049-8931
pubmed:author	pubmed-author:ChantDavidD, pubmed-author:McGrathJohnJ, pubmed-author:SahaSukantaS
pubmed:copyrightInfo	Copyright (c) 2008 John Wiley & Sons, Ltd.
pubmed:issnType	Print
pubmed:volume	17
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	55-61
pubmed:meshHeading	pubmed-meshheading:18286464-Humans, pubmed-meshheading:18286464-Incidence, pubmed-meshheading:18286464-Prevalence, pubmed-meshheading:18286464-Schizophrenia
pubmed:year	2008
pubmed:articleTitle	Meta-analyses of the incidence and prevalence of schizophrenia: conceptual and methodological issues.
pubmed:affiliation	Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Locked Bag 500, Richlands, Q4077, Australia.
pubmed:publicationType	Journal Article, Review, Meta-Analysis