| pubmed-article:18265929 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18265929 | lifeskim:mentions | umls-concept:C0030567 | lld:lifeskim |
| pubmed-article:18265929 | lifeskim:mentions | umls-concept:C0038868 | lld:lifeskim |
| pubmed-article:18265929 | lifeskim:mentions | umls-concept:C1704876 | lld:lifeskim |
| pubmed-article:18265929 | lifeskim:mentions | umls-concept:C0005854 | lld:lifeskim |
| pubmed-article:18265929 | lifeskim:mentions | umls-concept:C0242643 | lld:lifeskim |
| pubmed-article:18265929 | lifeskim:mentions | umls-concept:C0000294 | lld:lifeskim |
| pubmed-article:18265929 | lifeskim:mentions | umls-concept:C0393571 | lld:lifeskim |
| pubmed-article:18265929 | lifeskim:mentions | umls-concept:C1838103 | lld:lifeskim |
| pubmed-article:18265929 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:18265929 | lifeskim:mentions | umls-concept:C0205216 | lld:lifeskim |
| pubmed-article:18265929 | lifeskim:mentions | umls-concept:C0449258 | lld:lifeskim |
| pubmed-article:18265929 | lifeskim:mentions | umls-concept:C1537379 | lld:lifeskim |
| pubmed-article:18265929 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:18265929 | pubmed:dateCreated | 2008-7-3 | lld:pubmed |
| pubmed-article:18265929 | pubmed:abstractText | Decreased blood-brain barrier (BBB) efflux function of the P-glycoprotein (P-gp) transport system could facilitate the accumulation of toxic compounds in the brain, increasing the risk of neurodegenerative pathology such as Parkinson's disease (PD). This study investigated in vivo BBB P-gp function in patients with parkinsonian neurodegenerative syndromes, using [11C]-verapamil PET in PD, PSP and MSA patients. Regional differences in distribution volume were studied using SPM with higher uptake interpreted as reduced P-gp function. Advanced PD patients and PSP patients had increased [11C]-verapamil uptake in frontal white matter regions compared to controls; while de novo PD patients showed lower uptake in midbrain and frontal regions. PSP and MSA patients had increased uptake in the basal ganglia. Decreased BBB P-gp function seems a late event in neurodegenerative disorders, and could enhance continuous neurodegeneration. Lower [11C]-verapamil uptake in midbrain and frontal regions of de novo PD patients could indicate a regional up-regulation of P-gp function. | lld:pubmed |
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| pubmed-article:18265929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18265929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18265929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18265929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18265929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18265929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18265929 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18265929 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18265929 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18265929 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18265929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18265929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18265929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18265929 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18265929 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18265929 | pubmed:issn | 0300-9564 | lld:pubmed |
| pubmed-article:18265929 | pubmed:author | pubmed-author:LeendersK LKL | lld:pubmed |
| pubmed-article:18265929 | pubmed:author | pubmed-author:de VriesRR | lld:pubmed |
| pubmed-article:18265929 | pubmed:author | pubmed-author:de JongB MBM | lld:pubmed |
| pubmed-article:18265929 | pubmed:author | pubmed-author:PortmanAA | lld:pubmed |
| pubmed-article:18265929 | pubmed:author | pubmed-author:KortekaasRR | lld:pubmed |
| pubmed-article:18265929 | pubmed:author | pubmed-author:WillemsenA... | lld:pubmed |
| pubmed-article:18265929 | pubmed:author | pubmed-author:BartelsA LAL | lld:pubmed |
| pubmed-article:18265929 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:18265929 | pubmed:author | pubmed-author:de KlerkOO | lld:pubmed |
| pubmed-article:18265929 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18265929 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:18265929 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18265929 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18265929 | pubmed:pagination | 1001-9 | lld:pubmed |
| pubmed-article:18265929 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18265929 | pubmed:meshHeading | pubmed-meshheading:18265929... | lld:pubmed |
| pubmed-article:18265929 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18265929 | pubmed:articleTitle | Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA. | lld:pubmed |
| pubmed-article:18265929 | pubmed:affiliation | Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands. a.l.bartels@neuro.umcg.nl | lld:pubmed |
| pubmed-article:18265929 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18265929 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:18265929 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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