rdf:type |
|
lifeskim:mentions |
umls-concept:C0001128,
umls-concept:C0002520,
umls-concept:C0006118,
umls-concept:C0035647,
umls-concept:C0040399,
umls-concept:C0220781,
umls-concept:C0220825,
umls-concept:C1512628,
umls-concept:C1522485,
umls-concept:C1708632,
umls-concept:C1883254,
umls-concept:C2353562
|
pubmed:issue |
4
|
pubmed:dateCreated |
2008-2-18
|
pubmed:abstractText |
syn- and anti-1-amino-3-[2-iodoethenyl]-cyclobutane-1-carboxylic acid (syn-, anti-IVACBC 16, 17) and their analogue 1-amino-3-iodomethylene-cyclobutane-1-carboxylic acid (gem-IVACBC 18) were synthesized and radioiodoinated with [(123)I] in 34-43% delay-corrected yield. All these amino acids entered 9L gliosarcoma cells primarily via L-type transport in vitro with high uptake of 8-10% ID/1 x 10(6) cells. Biodistribution studies of [(123)I]16, 17 and 18 in rats with 9L gliosarcoma brain tumors demonstrated high tumor to brain ratios (4.7-7.3:1 at 60 min post-injection). In this model, syn-, anti-, and gem-[(123)I]IVACBC are promising radiotracers for SPECT brain tumor imaging.
|
pubmed:grant |
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
1464-3405
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
15
|
pubmed:volume |
18
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1264-8
|
pubmed:dateRevised |
2011-5-20
|
pubmed:meshHeading |
pubmed-meshheading:18258425-Animals,
pubmed-meshheading:18258425-Brain,
pubmed-meshheading:18258425-Brain Neoplasms,
pubmed-meshheading:18258425-Carboxylic Acids,
pubmed-meshheading:18258425-Cyclobutanes,
pubmed-meshheading:18258425-Gliosarcoma,
pubmed-meshheading:18258425-Iodine Radioisotopes,
pubmed-meshheading:18258425-Radiopharmaceuticals,
pubmed-meshheading:18258425-Rats,
pubmed-meshheading:18258425-Rats, Inbred F344,
pubmed-meshheading:18258425-Stereoisomerism,
pubmed-meshheading:18258425-Tissue Distribution,
pubmed-meshheading:18258425-Tomography, Emission-Computed, Single-Photon
|
pubmed:year |
2008
|
pubmed:articleTitle |
Synthesis and evaluation of [123I] labeled iodovinyl amino acids syn-, anti-1-amino-3-[2-iodoethenyl]-cyclobutane-1-carboxylic acid, and 1-amino-3-iodomethylene-cyclobutane-1-carboxylic acid as potential SPECT brain tumor imaging agents.
|
pubmed:affiliation |
Department of Radiology, Emory University, School of Medicine, Atlanta, GA 30322, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|