Source:http://linkedlifedata.com/resource/pubmed/id/18237598
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2008-2-1
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| pubmed:abstractText |
The ventilatory efficiency, minute ventilation (VE)/carbon dioxide production (VCO2), slope consistently provides valuable prognostic information in patients with heart failure (HF). Patients with a higher body mass index (BMI) have demonstrated an improved prognosis in the HF population, a phenomenon that has been termed the "obesity paradox." The purpose of this study was to evaluate the prognostic ability of the VE/VCO2 slope according to BMI in patients with HF. Seven-hundred four patients with HF (555 men, 149 women, mean age 56.8+/-13.4 years, ejection fraction 33.1+/-13.3%) with a BMI>or=18.5 kg/m2 underwent cardiopulmonary exercise testing. Subjects were divided into 3 BMI subgroups (18.5 to 24.9, 25.0 to 29.9, and >or=30 kg/m2). Each subject was tracked for major cardiac events (death, transplantation, left ventricular assist device implantation) for 2 years after testing. There were 86 major cardiac events (71 deaths, 10 transplantations, 5 left ventricular assist device implantations) during the 2-year tracking period (overall annual event rate 8.2%). The VE/VCO2 slope was the strongest prognostic marker in each BMI subgroup. Subjects in the highest BMI group had the lowest mean VE/VCO2 slope and the lowest rate of major cardiac events of the 3 groups. Multivariate Cox regression analysis showed that peak VO2 did not add additional prognostic value to the VE/VCO2 slope and was removed from the regression for each BMI subgroup. In conclusion, the findings of the present study indicate that VE/VCO2 slope maintains prognostic value irrespective of BMI in patients with HF.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0002-9149
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
101
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
348-52
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| pubmed:meshHeading |
pubmed-meshheading:18237598-Adult,
pubmed-meshheading:18237598-Aged,
pubmed-meshheading:18237598-Body Mass Index,
pubmed-meshheading:18237598-Carbon Dioxide,
pubmed-meshheading:18237598-Comorbidity,
pubmed-meshheading:18237598-Exercise Test,
pubmed-meshheading:18237598-Female,
pubmed-meshheading:18237598-Heart Failure,
pubmed-meshheading:18237598-Humans,
pubmed-meshheading:18237598-Male,
pubmed-meshheading:18237598-Middle Aged,
pubmed-meshheading:18237598-Obesity,
pubmed-meshheading:18237598-Oxygen Consumption,
pubmed-meshheading:18237598-Prognosis,
pubmed-meshheading:18237598-Pulmonary Ventilation,
pubmed-meshheading:18237598-ROC Curve,
pubmed-meshheading:18237598-Regression Analysis,
pubmed-meshheading:18237598-Stroke Volume
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| pubmed:year |
2008
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| pubmed:articleTitle |
Relation of the prognostic value of ventilatory efficiency to body mass index in patients with heart failure.
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| pubmed:affiliation |
LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina, USA. paul.chase@mosescone.com
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| pubmed:publicationType |
Journal Article
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