Linked Life Data

18235228

Source:http://linkedlifedata.com/resource/pubmed/id/18235228

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-3-3
pubmed:abstractText
During anaphase the mitotic spindle extends dramatically, promoting the segregation of the chromosomes into the two daughter cells. The spindle midzone, assembled at the onset of anaphase, is critical for this extension. How this assembly is linked to progression through the cell cycle is not fully understood. Our data show that in budding yeast the conserved phosphatase Cdc14, activated in early anaphase, regulates the formation of the spindle midzone. Cdc14 dephosphorylates residues of a core midzone component, the conserved microtubule bundling factor Ase1, that were previously phosphorylated by the cyclin-dependent kinase complex. In addition, Cdc14 activation is also indirectly responsible for midzone localization of the separase-Slk19 complex. This dual control of midzone assembly by Cdc14 is necessary for the formation of the focused and centered spindle midzone that drives the continuous and full elongation of the anaphase spindle. The identification of Ase1 as a key Cdc14 substrate elucidates how spindle midzone assembly is coordinated with the metaphase to anaphase transition.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1551-4005
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
283-6
pubmed:dateRevised
2009-4-2
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Assembling the spindle midzone in the right place at the right time.
pubmed:affiliation
Zentrum für Molekulare Biologie der Universität Heidelberg, Heidelberg, Germany.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't