| pubmed-article:18223001 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18223001 | lifeskim:mentions | umls-concept:C2339371 | lld:lifeskim |
| pubmed-article:18223001 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:18223001 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:18223001 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:18223001 | lifeskim:mentions | umls-concept:C2348693 | lld:lifeskim |
| pubmed-article:18223001 | lifeskim:mentions | umls-concept:C0678640 | lld:lifeskim |
| pubmed-article:18223001 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:18223001 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:18223001 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:18223001 | lifeskim:mentions | umls-concept:C0597484 | lld:lifeskim |
| pubmed-article:18223001 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:18223001 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:18223001 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:18223001 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:18223001 | pubmed:dateCreated | 2008-3-13 | lld:pubmed |
| pubmed-article:18223001 | pubmed:abstractText | The possible contribution of Na(+)-Ca(2+) exchange to the triggering of Ca(2+) release from the sarcoplasmic reticulum in ventricular cells remains unresolved. To gain insight into this issue, we measured the "trigger flux" of Ca(2+) crossing the cell membrane in rabbit ventricular myocytes with Ca(2+) release disabled pharmacologically. Under conditions that promote Ca(2+) entry via Na(+)-Ca(2+) exchange, internal [Na(+)] (10 mM), and positive membrane potential, the Ca(2+) trigger flux (measured using a fluorescent Ca(2+) indicator) was much greater than the Ca(2+) flux through the L-type Ca(2+) channel, indicating a significant contribution from Na(+)-Ca(2+) exchange to the trigger flux. The difference between total trigger flux and flux through L-type Ca(2+) channels was assessed by whole-cell patch-clamp recordings of Ca(2+) current and complementary experiments in which internal [Na(+)] was reduced. However, Ca(2+) entry via Na(+)-Ca(2+) exchange measured in the absence of L-type Ca(2+) current was considerably smaller than the amount inferred from the trigger flux measurements. From these results, we surmise that openings of L-type Ca(2+) channels increase [Ca(2+)] near Na(+)-Ca(2+) exchanger molecules and activate this protein. These results help to resolve seemingly contradictory results obtained previously and have implications for our understanding of the triggering of Ca(2+) release in heart cells under various conditions. | lld:pubmed |
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| pubmed-article:18223001 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18223001 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18223001 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18223001 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18223001 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18223001 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:18223001 | pubmed:issn | 1542-0086 | lld:pubmed |
| pubmed-article:18223001 | pubmed:author | pubmed-author:CannellMark... | lld:pubmed |
| pubmed-article:18223001 | pubmed:author | pubmed-author:SobieEric AEA | lld:pubmed |
| pubmed-article:18223001 | pubmed:author | pubmed-author:BridgeJohn... | lld:pubmed |
| pubmed-article:18223001 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18223001 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:18223001 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:18223001 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18223001 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18223001 | pubmed:pagination | L54-6 | lld:pubmed |
| pubmed-article:18223001 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18223001 | pubmed:meshHeading | pubmed-meshheading:18223001... | lld:pubmed |
| pubmed-article:18223001 | pubmed:meshHeading | pubmed-meshheading:18223001... | lld:pubmed |
| pubmed-article:18223001 | pubmed:meshHeading | pubmed-meshheading:18223001... | lld:pubmed |
| pubmed-article:18223001 | pubmed:meshHeading | pubmed-meshheading:18223001... | lld:pubmed |
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| pubmed-article:18223001 | pubmed:meshHeading | pubmed-meshheading:18223001... | lld:pubmed |
| pubmed-article:18223001 | pubmed:meshHeading | pubmed-meshheading:18223001... | lld:pubmed |
| pubmed-article:18223001 | pubmed:meshHeading | pubmed-meshheading:18223001... | lld:pubmed |
| pubmed-article:18223001 | pubmed:meshHeading | pubmed-meshheading:18223001... | lld:pubmed |
| pubmed-article:18223001 | pubmed:meshHeading | pubmed-meshheading:18223001... | lld:pubmed |
| pubmed-article:18223001 | pubmed:meshHeading | pubmed-meshheading:18223001... | lld:pubmed |
| pubmed-article:18223001 | pubmed:meshHeading | pubmed-meshheading:18223001... | lld:pubmed |
| pubmed-article:18223001 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18223001 | pubmed:articleTitle | Allosteric activation of Na+-Ca2+ exchange by L-type Ca2+ current augments the trigger flux for SR Ca2+ release in ventricular myocytes. | lld:pubmed |
| pubmed-article:18223001 | pubmed:publicationType | Letter | lld:pubmed |
| pubmed-article:18223001 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18223001 | lld:pubmed |
