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pubmed-article:18191398pubmed:abstractTextA series of selenophene analogues of the thiophene-containing antihypertensives milfasartan and eprosartan were prepared and tested for AT(1) receptor antagonist properties. All four selenophene compounds proved to be potent AT(1) receptor antagonists, with pK(B) estimates indicating that these selenides are at least as effective as the thiophene parent compounds at blocking AT(1) receptor mediated responses. These results reveal that replacement of sulfur with selenium in thiophene-containing sartans does not interfere with sartan activity.lld:pubmed
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pubmed-article:18191398pubmed:articleTitleSelenosartans: novel selenophene analogues of milfasartan and eprosartan.lld:pubmed
pubmed-article:18191398pubmed:affiliationSchool of Chemistry, The University of Melbourne, Vic. 3010, Australia.lld:pubmed
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