Linked Life Data

18178821

Source:http://linkedlifedata.com/resource/pubmed/id/18178821

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pubmed-article:18178821pubmed:abstractTextExperimental autoimmune encephalomyelitis (EAE) is one of the best-documented animal models of autoimmune disease. We examined the role of CD8+CD122+ regulatory T cells, which we previously identified as naturally occurring regulatory T cells that effectively regulate CD8+ T cells, in EAE. Depletion of CD8+CD122+ regulatory T cells by in vivo administration of anti-CD122 mAb resulted in persistent EAE symptoms. Transfer of CD8+CD122+ regulatory T cells into EAE mice at the peak EAE score clearly improved symptoms, indicating an important role of CD8+CD122+ regulatory T cells in the recovery phase of EAE. This was further confirmed by an increase and a decrease in the number of infiltrating T cells in the CNS and T cell cytokine production in mice that were depleted of or complemented with CD8+CD122+ cells. Furthermore, transfer of preactivated CD8+CD122+ regulatory T cells resulted in diminished EAE symptoms, especially in the recovery phase of EAE. These results elucidate the essential role of CD8+CD122+ regulatory T cells in the recovery phase of EAE and suggest the preventive effect of preactivated CD8+CD122+ regulatory T cells for EAE.lld:pubmed
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pubmed-article:18178821pubmed:articleTitleEssential role of CD8+CD122+ regulatory T cells in the recovery from experimental autoimmune encephalomyelitis.lld:pubmed
pubmed-article:18178821pubmed:affiliationDepartment of Immunology, Nagoya University Graduate School of Medicine, Japan.lld:pubmed
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pubmed-article:18178821pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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