Source:http://linkedlifedata.com/resource/pubmed/id/18160589
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2008-6-30
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| pubmed:abstractText |
We prospectively assessed associations of thrombophilia- hypofibrinolysis with central retinal vein occlusion (CRVO) (40 patients) and central retinal artery occlusion (CRAO) (9 patients). We used polymerase chain reaction measures for thrombophilia (factor V Leiden, prothrombin, C677T MTHFR, platelet glycoprotein PlA1/A2) and hypofibrinolysis (plasminogen activator inhibitor-1 4G4G). Serologic thrombophilia measures included protein C, protein S (total and free) and antithrombin III, homocysteine, lupus anticoagulant, anticardiolipin antibodies IgG-IgM, and factors VIII and XI. Serologic hypofibrinolysis measures included Lp(a) and plasminogen activator inhibitor activity. For comparison with 40 CRVO and 9 CRAO patients, 80 and 45 race-gender matched controls were studied. The factor V mutation was more common in CRVO (3/40, 8%) than controls (0/79, 0%), P = .036, as was high (>150%) factor VIII (12/40, 30%) versus (4/77, 5%), P = .0002. Low antithrombin III (<80%) was more common in CRVO (5/39, 13%) than in controls (2/73, 3%), P = .049. Homocysteine was high (> or =13.5 micromol/L) in 5/39 (13%) CRVO patients versus 2/78 controls (3%), P = .04. Three of 9 CRAO patients (33%) had low (<73%) protein C versus 2/37 controls (5%), P = .044. Two of 9 CRAO patients (22%) had high (> or =13.5 micromol/L) homocysteine versus 0/42 controls (0%), P =. 028. Four of 9 CRAO patients had the lupus anticoagulant (44%) versus 4/33 (12%) controls (P = .050). CRVO is associated with familial thrombophilia (factor V Leiden, factor VIII, low antithrombin III, homocysteinemia), and CRAO is associated with familial and acquired thrombophilia (low protein C, homocysteinemia, lupus anticoagulant), providing avenues for thromboprophylaxis, and triggering family screening.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1076-0296
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
14
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
286-94
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| pubmed:meshHeading |
pubmed-meshheading:18160589-Adult,
pubmed-meshheading:18160589-Aged,
pubmed-meshheading:18160589-Atherosclerosis,
pubmed-meshheading:18160589-Case-Control Studies,
pubmed-meshheading:18160589-Factor V,
pubmed-meshheading:18160589-Female,
pubmed-meshheading:18160589-Fibrinolysis,
pubmed-meshheading:18160589-Humans,
pubmed-meshheading:18160589-Male,
pubmed-meshheading:18160589-Middle Aged,
pubmed-meshheading:18160589-Pregnancy,
pubmed-meshheading:18160589-Pregnancy Complications, Cardiovascular,
pubmed-meshheading:18160589-Pregnancy Complications, Hematologic,
pubmed-meshheading:18160589-Pregnancy Outcome,
pubmed-meshheading:18160589-Prospective Studies,
pubmed-meshheading:18160589-Retinal Artery,
pubmed-meshheading:18160589-Retinal Artery Occlusion,
pubmed-meshheading:18160589-Retinal Vein Occlusion,
pubmed-meshheading:18160589-Risk Factors,
pubmed-meshheading:18160589-Thrombophilia,
pubmed-meshheading:18160589-Thrombosis
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| pubmed:year |
2008
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| pubmed:articleTitle |
Ocular vascular thrombotic events: central retinal vein and central retinal artery occlusions.
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| pubmed:affiliation |
Jewish Hospital Cholesterol Center, Cincinnati, OH 45229, USA. glueckch@healthall.com
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| pubmed:publicationType |
Journal Article
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