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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-15
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pubmed:abstractText |
To test the hypothesis that low socioeconomic status (SES) and the 5HTTLPR L allele are associated with increased cardiovascular reactivity (CVR) to stress in a larger sample and that SES and 5HTTLPR genotypes interact to enhance CVR to stress. CVR to mental stress has been proposed as one mechanism linking stress to the pathogenesis of cardiovascular disease. The more transcriptionally efficient long (L) allele of a polymorphism of the serotonin transporter gene promoter (5HTTLPR) has been found associated with increased risk of myocardial infarction. We found the long allele associated with larger CVR to mental stress in a preliminary study of 54 normal volunteers.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1534-7796
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pubmed:author |
pubmed-author:Ashley-KochAllisonA,
pubmed-author:BarefootJohn CJC,
pubmed-author:BrummettBeverly HBH,
pubmed-author:GaddeKishore MKM,
pubmed-author:HelmsMichael JMJ,
pubmed-author:KuhnCynthia MCM,
pubmed-author:LaneJames DJD,
pubmed-author:MarchukDouglas ADA,
pubmed-author:SchanbergSaul MSM,
pubmed-author:SieglerIlene CIC,
pubmed-author:SurwitRichard SRS,
pubmed-author:SvensonIngrid KIK,
pubmed-author:WilliamsRedford BRB
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pubmed:issnType |
Electronic
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
32-9
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pubmed:meshHeading |
pubmed-meshheading:18158371-Adult,
pubmed-meshheading:18158371-Aged,
pubmed-meshheading:18158371-Alleles,
pubmed-meshheading:18158371-Blood Pressure,
pubmed-meshheading:18158371-Cardiovascular Diseases,
pubmed-meshheading:18158371-Educational Status,
pubmed-meshheading:18158371-Fathers,
pubmed-meshheading:18158371-Female,
pubmed-meshheading:18158371-Genetic Predisposition to Disease,
pubmed-meshheading:18158371-Heart Rate,
pubmed-meshheading:18158371-Humans,
pubmed-meshheading:18158371-Income,
pubmed-meshheading:18158371-Male,
pubmed-meshheading:18158371-Middle Aged,
pubmed-meshheading:18158371-Polymorphism, Genetic,
pubmed-meshheading:18158371-Serotonin,
pubmed-meshheading:18158371-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:18158371-Social Class,
pubmed-meshheading:18158371-Stress, Psychological,
pubmed-meshheading:18158371-Tryptophan
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pubmed:year |
2008
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pubmed:articleTitle |
Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stress.
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pubmed:affiliation |
Department of Psychiatry and Behavioral Sciences, Box 3926, Duke University Medical Center, Durham, NC 27710, USA. redfordw@duke.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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