Linked Life Data

18081039

Source:http://linkedlifedata.com/resource/pubmed/id/18081039

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-12-26
pubmed:abstractText
CCR7(+ )central memory (T(CM)) CD4(+) T cells play a central role in long-term immunological memory. Recent reports indicate that a proportion of CD4(+) T(CM) is able to produce effector cytokines. The phenotype and the role of this subset remain unknown. We characterized cytokine-producing human CD4(+) T(CM) specific for cleared protein and persistent viral Ag. Our results demonstrate that the type of Ag stimulation is a major determinant of CD4(+) T(CM) differentiation. CMV-specific T(CM) were significantly more differentiated than protein Ag-specific T(CM) and included higher proportions of IFN-gamma-producing cells. The expression of killer cell lectin-like receptor G1 (KLRG1) by protein Ag- and CMV-specific T(CM) was associated with increased production of effector cytokines. KLRG1(+) T(CM) expressed high levels of CD127, suggesting that they can survive long term under the influence of IL-7. The induction of KLRG1(+) T(CM) may therefore represent an important target of vaccination against pathogens controlled by cellular immune responses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-2980
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-82
pubmed:meshHeading
pubmed-meshheading:18081039-Antigens, Differentiation, T-Lymphocyte, pubmed-meshheading:18081039-Antigens, Viral, pubmed-meshheading:18081039-CD4-Positive T-Lymphocytes, pubmed-meshheading:18081039-CD40 Ligand, pubmed-meshheading:18081039-Cell Differentiation, pubmed-meshheading:18081039-Cytokines, pubmed-meshheading:18081039-Cytomegalovirus, pubmed-meshheading:18081039-Flow Cytometry, pubmed-meshheading:18081039-Hepatitis B virus, pubmed-meshheading:18081039-Humans, pubmed-meshheading:18081039-Immunologic Memory, pubmed-meshheading:18081039-Interleukin-7 Receptor alpha Subunit, pubmed-meshheading:18081039-Phenotype, pubmed-meshheading:18081039-Receptors, CCR7, pubmed-meshheading:18081039-Receptors, KIR, pubmed-meshheading:18081039-T-Lymphocyte Subsets, pubmed-meshheading:18081039-Tetanus Toxoid
pubmed:year
2008
pubmed:articleTitle
Characterization of a subset of antigen-specific human central memory CD4+ T lymphocytes producing effector cytokines.
pubmed:affiliation
Institute for Medical Immunology, Université Libre de Bruxelles, Charleroi, Belgium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't