Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-2-1
pubmed:abstractText
Autism is a complex, heterogeneous, behaviorally-defined disorder characterized by disruptions of the nervous system and of other systems such as the pituitary-hypothalamic axis. In a previous genome wide screen, we reported linkage of autism with a 1.2 Megabase interval on chromosome 5q31. For the current study, we hypothesized that 3 of the genes in this region could be involved in the development of autism: 1) paired-like homeodomain transcription factor 1 (PITX1), which is a key regulator of hormones within the pituitary-hypothalamic axis, 2) neurogenin 1, a transcription factor involved in neurogenesis, and 3) histone family member Y (H2AFY), which is involved in X-chromosome inactivation in females and could explain the 4:1 male:female gender distortion present in autism.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-10196369, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-10398684, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-10417292, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-10581478, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-10613899, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-10782012, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-11353400, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-11427137, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-11452361, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-11481586, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-11682119, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-11875756, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-11923911, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-12220743, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-12669065, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-12915995, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-12944347, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-12959423, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-14606695, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-15056512, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-15121991, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-15389766, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-15497111, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-15789306, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-16027742, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-16080114, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-16222334, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-16263864, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-16917928, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-17173049, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-1928098, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-2175218, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-2745591, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-7792363, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-7814313, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-7977888, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-8675014, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-9315980, http://linkedlifedata.com/resource/pubmed/commentcorrection/18053270-9546821
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1471-2350
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
74
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
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