rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
26
|
pubmed:dateCreated |
2007-12-20
|
pubmed:abstractText |
Both enantiomers of 2-amino-2-methyl-4-iodo-3-(E)-butenoic acid (IVAIB, 5) were radioiodoinated in 65-72% yield. (S)-IVAIB entered 9L gliosarcoma cells primarily via A-type transport in vitro with higher uptake than (R)-IVAIB. Biodistribution studies in rats with 9L gliosarcoma brain tumors demonstrated higher tumor to brain ratios with (S)-IVAIB (75:1 at 1 h) than (R)-IVAIB (7.7:1). In this model, (S)-IVAIB is superior to (R)-IVAIB and is a promising radiotracer for brain tumor imaging.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0022-2623
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
27
|
pubmed:volume |
50
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
6718-21
|
pubmed:meshHeading |
pubmed-meshheading:18052089-Alanine,
pubmed-meshheading:18052089-Amino Acids,
pubmed-meshheading:18052089-Animals,
pubmed-meshheading:18052089-Biological Transport,
pubmed-meshheading:18052089-Brain,
pubmed-meshheading:18052089-Brain Neoplasms,
pubmed-meshheading:18052089-Fatty Acids, Monounsaturated,
pubmed-meshheading:18052089-Gliosarcoma,
pubmed-meshheading:18052089-Iodine Radioisotopes,
pubmed-meshheading:18052089-Male,
pubmed-meshheading:18052089-Neoplasm Transplantation,
pubmed-meshheading:18052089-Radiopharmaceuticals,
pubmed-meshheading:18052089-Rats,
pubmed-meshheading:18052089-Rats, Inbred F344,
pubmed-meshheading:18052089-Stereoisomerism,
pubmed-meshheading:18052089-Structure-Activity Relationship,
pubmed-meshheading:18052089-Tissue Distribution,
pubmed-meshheading:18052089-Tomography, Emission-Computed, Single-Photon,
pubmed-meshheading:18052089-Transplantation, Heterologous,
pubmed-meshheading:18052089-Tumor Cells, Cultured
|
pubmed:year |
2007
|
pubmed:articleTitle |
Facile stereospecific synthesis and biological evaluation of (S)- and (R)-2-amino-2-methyl-4-[123I]iodo-3-(E)-butenoic acid for brain tumor imaging with single photon emission computerized tomography.
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pubmed:affiliation |
mgoodma@emory.edu.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|