Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
26
pubmed:dateCreated
2007-12-20
pubmed:abstractText
Both enantiomers of 2-amino-2-methyl-4-iodo-3-(E)-butenoic acid (IVAIB, 5) were radioiodoinated in 65-72% yield. (S)-IVAIB entered 9L gliosarcoma cells primarily via A-type transport in vitro with higher uptake than (R)-IVAIB. Biodistribution studies in rats with 9L gliosarcoma brain tumors demonstrated higher tumor to brain ratios with (S)-IVAIB (75:1 at 1 h) than (R)-IVAIB (7.7:1). In this model, (S)-IVAIB is superior to (R)-IVAIB and is a promising radiotracer for brain tumor imaging.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6718-21
pubmed:meshHeading
pubmed-meshheading:18052089-Alanine, pubmed-meshheading:18052089-Amino Acids, pubmed-meshheading:18052089-Animals, pubmed-meshheading:18052089-Biological Transport, pubmed-meshheading:18052089-Brain, pubmed-meshheading:18052089-Brain Neoplasms, pubmed-meshheading:18052089-Fatty Acids, Monounsaturated, pubmed-meshheading:18052089-Gliosarcoma, pubmed-meshheading:18052089-Iodine Radioisotopes, pubmed-meshheading:18052089-Male, pubmed-meshheading:18052089-Neoplasm Transplantation, pubmed-meshheading:18052089-Radiopharmaceuticals, pubmed-meshheading:18052089-Rats, pubmed-meshheading:18052089-Rats, Inbred F344, pubmed-meshheading:18052089-Stereoisomerism, pubmed-meshheading:18052089-Structure-Activity Relationship, pubmed-meshheading:18052089-Tissue Distribution, pubmed-meshheading:18052089-Tomography, Emission-Computed, Single-Photon, pubmed-meshheading:18052089-Transplantation, Heterologous, pubmed-meshheading:18052089-Tumor Cells, Cultured
pubmed:year
2007
pubmed:articleTitle
Facile stereospecific synthesis and biological evaluation of (S)- and (R)-2-amino-2-methyl-4-[123I]iodo-3-(E)-butenoic acid for brain tumor imaging with single photon emission computerized tomography.
pubmed:affiliation
mgoodma@emory.edu.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural