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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2007-12-17
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pubmed:abstractText |
To investigate crosslinks between catabolic and anabolic pathways in articular cartilage by examining the synthesis and distribution pattern of microsomal prostaglandin E synthase 1 (mPGES-1) in healthy and osteoarthritic (OA) cartilage and analyzing its functional relationship to hypoxia-inducible factor 1alpha (HIF-1alpha) in primary articular chondrocytes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-methoxyestradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids, Dicarboxylic,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/HIF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Intramolecular Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/N-(2-cyclohexyloxy-4-nitrophenyl)met...,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Tubulin Modulators,
http://linkedlifedata.com/resource/pubmed/chemical/oxalylglycine,
http://linkedlifedata.com/resource/pubmed/chemical/prostaglandin-E synthase
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4084-94
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pubmed:meshHeading |
pubmed-meshheading:18050215-Aged,
pubmed-meshheading:18050215-Amino Acids, Dicarboxylic,
pubmed-meshheading:18050215-Cartilage, Articular,
pubmed-meshheading:18050215-Cell Hypoxia,
pubmed-meshheading:18050215-Cells, Cultured,
pubmed-meshheading:18050215-Chondrocytes,
pubmed-meshheading:18050215-Cyclooxygenase 2,
pubmed-meshheading:18050215-Cyclooxygenase Inhibitors,
pubmed-meshheading:18050215-Estradiol,
pubmed-meshheading:18050215-Humans,
pubmed-meshheading:18050215-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:18050215-Intramolecular Oxidoreductases,
pubmed-meshheading:18050215-Microsomes,
pubmed-meshheading:18050215-Middle Aged,
pubmed-meshheading:18050215-Nitrobenzenes,
pubmed-meshheading:18050215-Osteoarthritis,
pubmed-meshheading:18050215-Prostaglandins,
pubmed-meshheading:18050215-Sulfonamides,
pubmed-meshheading:18050215-Tubulin Modulators,
pubmed-meshheading:18050215-Up-Regulation
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pubmed:year |
2007
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pubmed:articleTitle |
Hypoxia-inducible factor 1alpha is involved in the prostaglandin metabolism of osteoarthritic cartilage through up-regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes.
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pubmed:affiliation |
University of Erlangen-Nuremberg, Erlangen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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