|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2008-1-3
|
|
pubmed:abstractText |
Idiopathic dilated cardiomyopathy (DCM) is a cardiac disorder characterized by left ventricular dilatation and impaired systolic contraction. It is a major cause of heart failure and heart transplantation. DCM is of genetic origin in approximately 30% of cases and genetically heterogeneous with the identification of numerous disease genes. However, many new disease genes remain to be discovered. Focusing on gene products located in the sarcomere of cardiomyocytes as disease-causing candidates, we screened the gene encoding the sarcomeric Z-band protein myopalladin (MYPN, OMIM 608517) for mutation.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0008-6363
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
77
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
118-25
|
|
pubmed:meshHeading |
pubmed-meshheading:18006477-Adolescent,
pubmed-meshheading:18006477-Adult,
pubmed-meshheading:18006477-Aged,
pubmed-meshheading:18006477-Amino Acid Sequence,
pubmed-meshheading:18006477-Base Sequence,
pubmed-meshheading:18006477-Cardiomyopathy, Dilated,
pubmed-meshheading:18006477-Cells, Cultured,
pubmed-meshheading:18006477-Female,
pubmed-meshheading:18006477-Humans,
pubmed-meshheading:18006477-Male,
pubmed-meshheading:18006477-Middle Aged,
pubmed-meshheading:18006477-Molecular Sequence Data,
pubmed-meshheading:18006477-Muscle Proteins,
pubmed-meshheading:18006477-Mutation,
pubmed-meshheading:18006477-Polymorphism, Single Nucleotide,
pubmed-meshheading:18006477-RNA, Messenger
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Mutations in the Z-band protein myopalladin gene and idiopathic dilated cardiomyopathy.
|
|
pubmed:affiliation |
INSERM, U621, Paris F-75013 France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
