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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-1-9
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pubmed:abstractText |
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressively disabling impairments in memory, cognition, and non-cognitive behavioural symptoms. Sporadic AD is multifactorial and genetically complex. While several monogenic mutations cause early-onset AD and gene alleles have been suggested as AD susceptibility factors, the only extensively validated susceptibility gene for late-onset AD is the apolipoprotein E (APOE) epsilon4 allele. Alleles of the APOE gene do not account for all of the genetic load calculated to be responsible for AD predisposition. Recently, polymorphisms across the neuronal sortilin-related receptor (SORL1) gene were shown to be significantly associated with AD in several cohorts. Here we present the results of our large case-control whole-genome scan at over 500,000 polymorphisms which presents weak evidence for association and potentially narrows the association interval.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1660-2862
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pubmed:author |
pubmed-author:BeachThomasT,
pubmed-author:BrydenLeslieL,
pubmed-author:CoonKeith DKD,
pubmed-author:CraigDavid WDW,
pubmed-author:HalperinRebecca FRF,
pubmed-author:HardyJohnJ,
pubmed-author:HewardChristopher BCB,
pubmed-author:Hu-LinceDianeD,
pubmed-author:HuentelmanMatthew JMJ,
pubmed-author:JoshipuraKetaK,
pubmed-author:KaleemMonaM,
pubmed-author:LeungDorisD,
pubmed-author:MarloweLaurenL,
pubmed-author:MyersAmanda JAJ,
pubmed-author:PapassotiropoulosAndreasA,
pubmed-author:PearsonJohn VJV,
pubmed-author:RavidRivkaR,
pubmed-author:ReimanEric MEM,
pubmed-author:RogersJosephJ,
pubmed-author:StephanDietrich ADA,
pubmed-author:WalkerDouglasD,
pubmed-author:WebsterJennifer AJA,
pubmed-author:ZismannVictoria LVL
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pubmed:copyrightInfo |
2007 S. Karger AG, Basel
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
60-4
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pubmed:meshHeading |
pubmed-meshheading:17975299-Aged,
pubmed-meshheading:17975299-Aged, 80 and over,
pubmed-meshheading:17975299-Alzheimer Disease,
pubmed-meshheading:17975299-Case-Control Studies,
pubmed-meshheading:17975299-Female,
pubmed-meshheading:17975299-Genetic Markers,
pubmed-meshheading:17975299-Genetic Predisposition to Disease,
pubmed-meshheading:17975299-Humans,
pubmed-meshheading:17975299-LDL-Receptor Related Proteins,
pubmed-meshheading:17975299-Male,
pubmed-meshheading:17975299-Membrane Transport Proteins,
pubmed-meshheading:17975299-Polymorphism, Genetic
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pubmed:year |
2008
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pubmed:articleTitle |
Sorl1 as an Alzheimer's disease predisposition gene?
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pubmed:affiliation |
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Ariz., USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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