Source:http://linkedlifedata.com/resource/pubmed/id/17971512
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-1-14
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| pubmed:abstractText |
The gain in muscle mass as a result of resistance training is dependent on changes in both anabolic and catabolic reactions. A frequency of two to three exercise sessions per week is considered optimal for muscle gain in untrained individuals. Our hypothesis was that a second exercise session would enlarge the anabolic response and/or decrease the catabolic response. Eight male subjects performed resistance exercise on two occasions separated by 2 days. Muscle biopsies were taken from the vastus lateralis before and 15 min, 1 h, and 2 h after exercise. Exercise led to severalfold increases in phosphorylation of mTOR at Ser2448, p70 S6 kinase (p70S6k) at Ser424/Thr421 and Thr389, and ribosomal protein S6, which persisted for up to 2 h of recovery on both occasions. There was a tendency toward a larger effect of the second exercise on p70S6k and S6, but the difference did not reach statistical significance. The mRNA expression of MuRF-1, which increased after exercise, was 30% lower after the second exercise session than after the first one. MAFbx expression was not altered after exercise but downregulated 30% 48 h later, whereas myostatin expression was reduced by 45% after the first exercise and remained low until after the second exercise session. The results indicate that 1) changes in expression of genes involved in protein degradation are attenuated as a response to repetitive resistance training with minor additional increases in enzymes regulating protein synthesis and 2) the two ubiquitin ligases, MuRF-1 and MAFbx, are differently affected by the exercise as well as by repeated exercise.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/FBXO32 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Lactic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/MTOR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Protein S6 Kinases, 70-kDa,
http://linkedlifedata.com/resource/pubmed/chemical/SKP Cullin F-Box Protein Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/TRIM63 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0193-1849
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
294
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
E43-51
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:17971512-Adult,
pubmed-meshheading:17971512-Blood Glucose,
pubmed-meshheading:17971512-Exercise,
pubmed-meshheading:17971512-Gene Expression,
pubmed-meshheading:17971512-Humans,
pubmed-meshheading:17971512-Lactic Acid,
pubmed-meshheading:17971512-Male,
pubmed-meshheading:17971512-Muscle, Skeletal,
pubmed-meshheading:17971512-Muscle Proteins,
pubmed-meshheading:17971512-Muscle Strength,
pubmed-meshheading:17971512-Phosphorylation,
pubmed-meshheading:17971512-Protein Kinases,
pubmed-meshheading:17971512-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:17971512-RNA, Messenger,
pubmed-meshheading:17971512-Ribosomal Protein S6 Kinases, 70-kDa,
pubmed-meshheading:17971512-SKP Cullin F-Box Protein Ligases,
pubmed-meshheading:17971512-Signal Transduction,
pubmed-meshheading:17971512-TOR Serine-Threonine Kinases,
pubmed-meshheading:17971512-Ubiquitin-Protein Ligases
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| pubmed:year |
2008
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| pubmed:articleTitle |
Repeated resistance exercise training induces different changes in mRNA expression of MAFbx and MuRF-1 in human skeletal muscle.
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| pubmed:affiliation |
Astrand Laboratory, Swedish School of Sport and Health Sciences, Karolinska University Hospital, Karolinska Institutet, Box 5626, Stockholm, S-114 86, Sweden.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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