Linked Life Data

17967023

Source:http://linkedlifedata.com/resource/pubmed/id/17967023

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
46
pubmed:dateCreated
2007-11-16
pubmed:abstractText
Water-soluble macromolecular chain transfer agents (Macro-CTAs) were developed for the microwave-assisted precipitation polymerization of N-isopropylacrylamide. Two types of Macro-CTAs, amphiphilic (Macro-CTA1) and hydrophilic (Macro-CTA2), were investigated regarding their activity for the facile formation of nanoparticles and double hydrophilic block copolymers by RAFT processes. While both Macro-CTAs functioned as steric stabilization agents, the variation in their surface activity afforded different levels of control over the resulting nanoparticles in the presence of cross-linkers. The cross-linked nanoparticles produced using the amphiphilic Macro-CTA1 were less uniform than those produced using the fully hydrophilic Macro-CTA2. The nanoparticles spontaneously formed core-shell structures with surface functionalities derived from those of the Macro-CTAs. In the absence of cross-linkers, both types of Macro-CTAs showed excellent control over the RAFT precipitation polymerization process with well-defined, double hydrophilic block copolymers being obtained. The power of combining microwave irradiation with RAFT procedures was evident in the high efficiency and high solids content of the polymerization systems. In addition, the "living" nature of the nanoparticles allowed for further copolymerization leading to multiresponsive nanostructured hydrogels containing surface functional groups, which were used for surface bioconjugation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0002-7863
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
129
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
14493-9
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Facile RAFT precipitation polymerization for the microwave-assisted synthesis of well-defined, double hydrophilic block copolymers and nanostructured hydrogels.
pubmed:affiliation
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural