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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-12-20
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pubmed:abstractText |
The matrix metalloproteinases (MMPs) are enzymes that cleave various components of the extracellular matrix (ECM) and basement membranes. MMPs are expressed in melanocytes and their overexpression has been linked to tumor development, progression and metastasis. At the genetic level, the following functional promoter polymorphisms are known to modify the gene transcription: -1306 C/T and -735 C/T in the MMP2 gene, and -1171 5A/6A in the MMP3 gene. Functional polymorphisms in MMP genes' promoter regions may modulate the risk for melanoma progression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17958893-10878545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17958893-10951266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17958893-11114309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17958893-11286131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17958893-11544020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17958893-11802203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17958893-12404291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17958893-12473595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17958893-12813898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17958893-15036262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17958893-15492291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17958893-15701845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17958893-15949868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17958893-16258177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17958893-16311244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17958893-8662692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17958893-8958806
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1477-5751
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pubmed:author |
pubmed-author:BerwickMarianneM,
pubmed-author:BusamKlausK,
pubmed-author:CoitDanielD,
pubmed-author:CotignolaJavierJ,
pubmed-author:HalpernAllanA,
pubmed-author:HoughtonAlanA,
pubmed-author:IshillNicoleN,
pubmed-author:OrlowIreneI,
pubmed-author:PatelAmiA,
pubmed-author:RoyPampaP,
pubmed-author:ShahShivangS
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17958893-Adolescent,
pubmed-meshheading:17958893-Adult,
pubmed-meshheading:17958893-Aged,
pubmed-meshheading:17958893-Aged, 80 and over,
pubmed-meshheading:17958893-Child,
pubmed-meshheading:17958893-Child, Preschool,
pubmed-meshheading:17958893-Disease Progression,
pubmed-meshheading:17958893-Female,
pubmed-meshheading:17958893-Humans,
pubmed-meshheading:17958893-Male,
pubmed-meshheading:17958893-Matrix Metalloproteinase 2,
pubmed-meshheading:17958893-Matrix Metalloproteinase 3,
pubmed-meshheading:17958893-Melanoma,
pubmed-meshheading:17958893-Middle Aged,
pubmed-meshheading:17958893-Polymerase Chain Reaction,
pubmed-meshheading:17958893-Polymorphism, Genetic,
pubmed-meshheading:17958893-Promoter Regions, Genetic
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pubmed:year |
2007
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pubmed:articleTitle |
Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progression.
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pubmed:affiliation |
Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. javiercoty@gmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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