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rdf:type |
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lifeskim:mentions |
|
|
pubmed:issue |
23
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pubmed:dateCreated |
2007-11-6
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pubmed:abstractText |
The synthesis of novel dipeptidyl alpha-fluorovinyl sulfones using a Horner-Wadsworth-Emmons approach on N-Boc-l-phenylalaninal is described. Inhibitory assays against a Leishmania mexicana cysteine protease (CPB2.8DeltaCTE) revealed low biological activity. Relative rates of Michael additions of 2'-(phenethyl)thiol with vinyl sulfone and alpha-fluorovinyl sulfone were determined, and ab initio calculations on several Michael acceptor model structures were performed; both were in agreement with the biological testing results.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1464-3405
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|
pubmed:author |
|
|
pubmed:issnType |
Electronic
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|
pubmed:day |
1
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6563-6
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|
pubmed:meshHeading |
|
|
pubmed:year |
2007
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|
pubmed:articleTitle |
Dipeptidyl alpha-fluorovinyl Michael acceptors: synthesis and activity against cysteine proteases.
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|
pubmed:affiliation |
Laboratory of Medicinal Chemistry, University of Antwerp, Universiteitsplein 1, BE-2610 Antwerp, Belgium.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
