Linked Life Data

17934100

Source:http://linkedlifedata.com/resource/pubmed/id/17934100

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-10-15
pubmed:abstractText
T cells from patients with systemic lupus erythematosus exhibit a notable array of defects that probably contribute to the origin and development of the disease. Such abnormalities include an abnormal response to stimulation, aberrant expression of molecules that play key roles in intracellular signalling pathways, altered transcription factor activation and binding, and skewed gene expression. The combination of these alterations leads the cell to the expression of a particular phenotype that intense research has gradually uncovered over the last years. The aim of this article is to review the findings that have allowed us to better understand the behaviour of the lupus T cell and highlight the molecules that represent potential therapeutic targets.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0003-4967
pubmed:author
pubmed:issnType
Print
pubmed:volume
66 Suppl 3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
iii65-9
pubmed:dateRevised
2010-11-2
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Systemic lupus erythematosus: new molecular targets.
pubmed:affiliation
Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, 4 Blackfan Circle, HIM-244, Boston, MA 02115, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review, Research Support, N.I.H., Extramural