17888982

Source:http://linkedlifedata.com/resource/pubmed/id/17888982

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0012022, umls-concept:C0018791, umls-concept:C1148673, umls-concept:C1367307, umls-concept:C1879547
pubmed:issue	4
pubmed:dateCreated	2007-9-24
pubmed:abstractText	Previously, we have shown that magnesium supplemented potassium (DSA) cardioplegia and DSA containing diazoxide (DSA+DZX) significantly decrease apoptosis after ischemia. The mechanism for this enhanced cardioprotection was unknown, but we believed that alterations in signal transducers and activators of transcription (STATs) may play a role. To investigate this hypothesis, we examined the effects of DSA and DSA+DZX cardioplegia on STAT1/3 phosphorylation and DNA binding in the in situ blood perfused pig heart model.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/15030100R
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Cardioplegic Solutions, http://linkedlifedata.com/resource/pubmed/chemical/DNA, http://linkedlifedata.com/resource/pubmed/chemical/Diazoxide, http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	1552-6259
pubmed:author	pubmed-author:HsiehYng-JuYJ, pubmed-author:LevitskySidneyS, pubmed-author:McCullyJames DJD, pubmed-author:WakiyamaHidetakaH
pubmed:issnType	Electronic
pubmed:volume	84
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1272-8
pubmed:meshHeading	pubmed-meshheading:17888982-Animals, pubmed-meshheading:17888982-Apoptosis, pubmed-meshheading:17888982-Binding Sites, pubmed-meshheading:17888982-Blotting, Western, pubmed-meshheading:17888982-Cardioplegic Solutions, pubmed-meshheading:17888982-DNA, pubmed-meshheading:17888982-Diazoxide, pubmed-meshheading:17888982-Disease Models, Animal, pubmed-meshheading:17888982-Electrophoresis, pubmed-meshheading:17888982-Female, pubmed-meshheading:17888982-Heart Arrest, Induced, pubmed-meshheading:17888982-Ischemic Preconditioning, Myocardial, pubmed-meshheading:17888982-Male, pubmed-meshheading:17888982-Mitochondria, Heart, pubmed-meshheading:17888982-Myocardial Reperfusion Injury, pubmed-meshheading:17888982-Phosphorylation, pubmed-meshheading:17888982-Random Allocation, pubmed-meshheading:17888982-STAT3 Transcription Factor, pubmed-meshheading:17888982-Sensitivity and Specificity, pubmed-meshheading:17888982-Swine, pubmed-meshheading:17888982-Tyrosine
pubmed:year	2007
pubmed:articleTitle	Cardioplegia and diazoxide modulate STAT3 activation and DNA binding.
pubmed:affiliation	Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA.
pubmed:publicationType	Journal Article