pubmed-article:17882232 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17882232 | lifeskim:mentions | umls-concept:C1708335 | lld:lifeskim |
pubmed-article:17882232 | lifeskim:mentions | umls-concept:C0599851 | lld:lifeskim |
pubmed-article:17882232 | lifeskim:mentions | umls-concept:C0041249 | lld:lifeskim |
pubmed-article:17882232 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
pubmed-article:17882232 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
pubmed-article:17882232 | lifeskim:mentions | umls-concept:C0849912 | lld:lifeskim |
pubmed-article:17882232 | lifeskim:mentions | umls-concept:C1709694 | lld:lifeskim |
pubmed-article:17882232 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
pubmed-article:17882232 | pubmed:issue | 8 | lld:pubmed |
pubmed-article:17882232 | pubmed:dateCreated | 2008-6-12 | lld:pubmed |
pubmed-article:17882232 | pubmed:abstractText | The processing of affective material is known to be modulated by serotonin (5-HT), but few studies have used neurophysiological measures to characterize the effect of changes in 5-HT on neural responses to emotional stimuli. We used functional magnetic resonance imaging to investigate the effect of acute tryptophan depletion, which reduces central 5-HT synthesis, on neural responses to emotionally valenced verbal stimuli. Though no participants experienced significant mood change, emotional information processing was substantially modified following 5-HT depletion. A behavioral bias toward positive stimuli was attenuated following depletion, which was accompanied by increased hemodynamic responses during the processing of emotional words in several subcortical structures. Inter-individual differences in tryptophan depletion-elicited anxiety correlated positively with the caudate bias toward negative stimuli. These data suggest that 5-HT may play an important role in mediating automatic negative attentional biases in major depression, as well as resilience against negative distracting stimuli in never-depressed individuals. | lld:pubmed |
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pubmed-article:17882232 | pubmed:language | eng | lld:pubmed |
pubmed-article:17882232 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17882232 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:17882232 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17882232 | pubmed:month | Jul | lld:pubmed |
pubmed-article:17882232 | pubmed:issn | 0893-133X | lld:pubmed |
pubmed-article:17882232 | pubmed:author | pubmed-author:DrevetsWayne... | lld:pubmed |
pubmed-article:17882232 | pubmed:author | pubmed-author:SahakianBarba... | lld:pubmed |
pubmed-article:17882232 | pubmed:author | pubmed-author:HaslerGregorG | lld:pubmed |
pubmed-article:17882232 | pubmed:author | pubmed-author:RoiserJonatha... | lld:pubmed |
pubmed-article:17882232 | pubmed:author | pubmed-author:FrommStephen... | lld:pubmed |
pubmed-article:17882232 | pubmed:author | pubmed-author:LevyJameyJ | lld:pubmed |
pubmed-article:17882232 | pubmed:author | pubmed-author:WangHongyeH | lld:pubmed |
pubmed-article:17882232 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:17882232 | pubmed:volume | 33 | lld:pubmed |
pubmed-article:17882232 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17882232 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17882232 | pubmed:pagination | 1992-2006 | lld:pubmed |
pubmed-article:17882232 | pubmed:dateRevised | 2011-5-18 | lld:pubmed |
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