|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2007-9-14
|
|
pubmed:abstractText |
Reciprocal chromosomal translocations involving the MLL gene at chromosome region 11q23 are recurring cytogenetic abnormalities in both de novo and therapy-related acute myeloid leukemia (AML) and in acute lymphoblastic leukemia. We report a t(4;11)(p12;q23) with rearrangement of MLL and FRYL (also known as AF4p12), a human homolog to the furry gene of Drosophila, in an adult patient with therapy-related AML after fludarabine and rituximab therapy for small lymphocytic lymphoma and radiation therapy for breast carcinoma. To our knowledge, t(4;11)(p12;q23) has been reported in two previous patients, and MLL and FRYL rearrangement was demonstrated in one of them. Both of the previous patients had therapy-related leukemias after exposure to topoisomerase II inhibitors, whereas our patient had received cytotoxic therapy that did not include a topoisomerase II inhibitor. Thus, t(4;11)(p12;q23) with MLL and FRYL involvement represents a new recurring 11q23 translocation, to date seen only in therapy-related acute leukemias.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AFF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MLL protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid-Lymphoid Leukemia Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Vidarabine,
http://linkedlifedata.com/resource/pubmed/chemical/fludarabine,
http://linkedlifedata.com/resource/pubmed/chemical/rituximab
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0165-4608
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
177
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
143-6
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:17854671-Acute Disease,
pubmed-meshheading:17854671-Antibodies, Monoclonal,
pubmed-meshheading:17854671-Antibodies, Monoclonal, Murine-Derived,
pubmed-meshheading:17854671-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:17854671-Chromosomes, Human, Pair 11,
pubmed-meshheading:17854671-Chromosomes, Human, Pair 4,
pubmed-meshheading:17854671-DNA-Binding Proteins,
pubmed-meshheading:17854671-Female,
pubmed-meshheading:17854671-Gene Rearrangement,
pubmed-meshheading:17854671-Humans,
pubmed-meshheading:17854671-In Situ Hybridization, Fluorescence,
pubmed-meshheading:17854671-Karyotyping,
pubmed-meshheading:17854671-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:17854671-Leukemia, Myeloid,
pubmed-meshheading:17854671-Middle Aged,
pubmed-meshheading:17854671-Myeloid-Lymphoid Leukemia Protein,
pubmed-meshheading:17854671-Nuclear Proteins,
pubmed-meshheading:17854671-Translocation, Genetic,
pubmed-meshheading:17854671-Vidarabine
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Translocation (4;11)(p12;q23) with rearrangement of FRYL and MLL in therapy-related acute myeloid leukemia.
|
|
pubmed:affiliation |
Clinical Cytogenetics Laboratory, DNA Microarray and Genomics Facility, Departments of Pathology and Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA. Sheila.Sait@roswellpark.org
|
|
pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, N.I.H., Extramural
|
