Linked Life Data

17827440

Source:http://linkedlifedata.com/resource/pubmed/id/17827440

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2007-9-10
pubmed:abstractText
MicroRNAs (miRNAs or mirs) are small, non-coding RNAs that bind specific mRNAs and decrease their translation or increase their degradation. miRNAs may modulate the formation and maintenance of tumors by regulating oncogene and tumor suppressor expression. For example, overexpression of a subset of miRNAs has been inversely correlated with certain tumor phenotypes, suggesting a role in tumor suppression. Pairs of oncogenes and the corresponding miRNAs that attenuate their expression have been recently identified. These miRNAs, or "anti-oncomirs," can act as natural inhibitors of oncogene function, indicating the possibility that they might be developed as novel therapeutics.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1534-0384
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
199-202, 180
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Anti-oncomir suppression of tumor phenotypes.
pubmed:affiliation
Department of Medicine, University of California, San Francisco, CA 94143, USA. andrei.goga@ucsf.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural