| pubmed-article:17804457 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17804457 | lifeskim:mentions | umls-concept:C0022675 | lld:lifeskim |
| pubmed-article:17804457 | lifeskim:mentions | umls-concept:C1420193 | lld:lifeskim |
| pubmed-article:17804457 | lifeskim:mentions | umls-concept:C0032821 | lld:lifeskim |
| pubmed-article:17804457 | lifeskim:mentions | umls-concept:C0596019 | lld:lifeskim |
| pubmed-article:17804457 | lifeskim:mentions | umls-concept:C1422673 | lld:lifeskim |
| pubmed-article:17804457 | lifeskim:mentions | umls-concept:C1621574 | lld:lifeskim |
| pubmed-article:17804457 | lifeskim:mentions | umls-concept:C0178499 | lld:lifeskim |
| pubmed-article:17804457 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17804457 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:17804457 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:17804457 | pubmed:dateCreated | 2007-11-28 | lld:pubmed |
| pubmed-article:17804457 | pubmed:abstractText | In the present study, the effect of potassium depletion on the expression of acid-base transporters in the collecting duct was examined. Toward this end rats were fed a potassium-free diet for 3 weeks. Thereafter, the expression of the basolateral chloride/bicarbonate exchangers AE1 and SLC26A7 and the apical H(+)-ATPase was examined by northern hybridization, immunoblot analysis and immunofluorescence labelling. The mRNA expression of AE1 increased by a robust approximately 500% in the cortex and approximately 70% in the outer medulla, which translated into a huge increase in AE1 protein abundance in the cortex and a moderate increase in the outer medulla in K-depletion. The mRNA expression of SLC26A7 did not change significantly but its protein abundance showed a robust increase in the outer medulla. The expression of SLC26A7 remained undetected in the cortex in K-depleted rats. The post translational increase in SLC26A7 membrane abundance in potassium depletion was recapitulated in vitro using epitope-tagged SLC26A7. H(+)-ATPase displayed enhanced apical plasma membrane immunoreactivity in the OMCD in K-depletion. We suggest that the up-regulation of SLC26A7 and AE1 on the basolateral membrane of A-intercalated cells in the OMCD and CCD, respectively, along with H(+)-ATPase on the apical membrane, contributes to enhanced bicarbonate absorption in the collecting duct in K-depletion. | lld:pubmed |
| pubmed-article:17804457 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17804457 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17804457 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17804457 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17804457 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17804457 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17804457 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17804457 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17804457 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17804457 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17804457 | pubmed:issn | 0931-0509 | lld:pubmed |
| pubmed-article:17804457 | pubmed:author | pubmed-author:SoleimaniMano... | lld:pubmed |
| pubmed-article:17804457 | pubmed:author | pubmed-author:MEOLL | lld:pubmed |
| pubmed-article:17804457 | pubmed:author | pubmed-author:KereJuhaJ | lld:pubmed |
| pubmed-article:17804457 | pubmed:author | pubmed-author:KujalaMinnaM | lld:pubmed |
| pubmed-article:17804457 | pubmed:author | pubmed-author:AmlalHassaneH | lld:pubmed |
| pubmed-article:17804457 | pubmed:author | pubmed-author:BaroneSharonS | lld:pubmed |
| pubmed-article:17804457 | pubmed:author | pubmed-author:KaretFionaF | lld:pubmed |
| pubmed-article:17804457 | pubmed:author | pubmed-author:BlanchardAnnA | lld:pubmed |
| pubmed-article:17804457 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17804457 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:17804457 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17804457 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17804457 | pubmed:pagination | 3462-70 | lld:pubmed |
| pubmed-article:17804457 | pubmed:meshHeading | pubmed-meshheading:17804457... | lld:pubmed |
| pubmed-article:17804457 | pubmed:meshHeading | pubmed-meshheading:17804457... | lld:pubmed |
| pubmed-article:17804457 | pubmed:meshHeading | pubmed-meshheading:17804457... | lld:pubmed |
| pubmed-article:17804457 | pubmed:meshHeading | pubmed-meshheading:17804457... | lld:pubmed |
| pubmed-article:17804457 | pubmed:meshHeading | pubmed-meshheading:17804457... | lld:pubmed |
| pubmed-article:17804457 | pubmed:meshHeading | pubmed-meshheading:17804457... | lld:pubmed |
| pubmed-article:17804457 | pubmed:meshHeading | pubmed-meshheading:17804457... | lld:pubmed |
| pubmed-article:17804457 | pubmed:meshHeading | pubmed-meshheading:17804457... | lld:pubmed |
| pubmed-article:17804457 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17804457 | pubmed:articleTitle | Regulation of the basolateral chloride/base exchangers AE1 and SLC26A7 in the kidney collecting duct in potassium depletion. | lld:pubmed |
| pubmed-article:17804457 | pubmed:affiliation | Department of Medicine, University of Cincinnati, 231 Albert Sabin Way, MSB G259, Cincinnati, OH 45267-0585, USA. | lld:pubmed |
| pubmed-article:17804457 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17804457 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17804457 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:24216 | entrezgene:pubmed | pubmed-article:17804457 | lld:entrezgene |
| entrez-gene:25386 | entrezgene:pubmed | pubmed-article:17804457 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17804457 | lld:pubmed |
