Source:http://linkedlifedata.com/resource/pubmed/id/17785291
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2007-9-5
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| pubmed:abstractText |
HMGB1 is a nonhistone nuclear protein that can serve as a cytokine and activate innate immunity. The translocation of this molecule from the inside to the outside of cells is a critical event in inflammation, occurring following activation of certain Toll-like receptors (TLRs) as well as during the course of apoptotic as well as necrotic cell death. Because the kinetics of HMGB1 release differs from that of a conventional cytokine, it provides a broader therapeutic window and may be an important new target of therapy for inflammatory, autoimmune, and infectious diseases.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0077-8923
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
1109
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
58-65
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| pubmed:meshHeading |
pubmed-meshheading:17785291-Animals,
pubmed-meshheading:17785291-Cell Death,
pubmed-meshheading:17785291-HMGB1 Protein,
pubmed-meshheading:17785291-Humans,
pubmed-meshheading:17785291-Ligands,
pubmed-meshheading:17785291-Lymphocyte Activation,
pubmed-meshheading:17785291-Macrophages,
pubmed-meshheading:17785291-Models, Immunological,
pubmed-meshheading:17785291-Toll-Like Receptors
|
| pubmed:year |
2007
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| pubmed:articleTitle |
Role of Toll-like receptors in HMGB1 release from macrophages.
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| pubmed:affiliation |
Medical Research Service, Durham VA Medical Center, Durham, North Carolina 27705, USA. dpiset@acpub.duke.edu
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| pubmed:publicationType |
Journal Article
|