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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1976-7-6
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pubmed:abstractText |
In a phase II trial the effect of vincristine as a single agent was evaluated in patients with small-cell anaplastic carcinoma of the lung. The dosage of vincristine was 1.5 mg/m2/week given iv for 4 weeks, followed by 1.5 mg/m2 given every other week with dose modifications according to neurologic tolerance. Nineteen of 27 patients included in the study were evaluable. Objective response was observed in eight patients (42%) including three who were not previously treated and five who were previously treated. The median duration of response was 60 days (range, 21-182 days) with the response always occurring within 4 weeks. This study demonstrates that vincristine is an active agent for small-cell anaplastic carcinoma without cross resistance to CCNU, cyclophosphamide, or methotrexate.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
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pubmed:issn |
0361-5960
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
239-42
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:177209-Aged,
pubmed-meshheading:177209-Carcinoma, Small Cell,
pubmed-meshheading:177209-Drug Evaluation,
pubmed-meshheading:177209-Female,
pubmed-meshheading:177209-Gastroenteritis,
pubmed-meshheading:177209-Humans,
pubmed-meshheading:177209-Lung Neoplasms,
pubmed-meshheading:177209-Male,
pubmed-meshheading:177209-Middle Aged,
pubmed-meshheading:177209-Neuromuscular Diseases,
pubmed-meshheading:177209-Remission, Spontaneous,
pubmed-meshheading:177209-Vincristine
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pubmed:year |
1976
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pubmed:articleTitle |
Vincristine (NSC-67574) in the treatment of small-cell anaplastic carcinoma of the lung.
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pubmed:publicationType |
Journal Article
|