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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-2-1
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pubmed:abstractText |
TNFalpha is a pro-inflammatory cytokine that induces endothelial dysfunction and promotes atherosclerosis progression. Down-regulation of lysyl oxidase (LOX), a key enzyme in extracellular matrix maturation, by pro-atherogenic risk factors such as LDL and homocysteine, is associated with an impairment of endothelial barrier function. Our hypothesis is that the inflammatory cytokine TNFalpha could also modulate LOX expression/function in endothelial cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1879-1484
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
196
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
558-64
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pubmed:meshHeading |
pubmed-meshheading:17673218-Animals,
pubmed-meshheading:17673218-Aorta,
pubmed-meshheading:17673218-Apoptosis,
pubmed-meshheading:17673218-Cattle,
pubmed-meshheading:17673218-Cells, Cultured,
pubmed-meshheading:17673218-Down-Regulation,
pubmed-meshheading:17673218-Endothelium, Vascular,
pubmed-meshheading:17673218-Humans,
pubmed-meshheading:17673218-Male,
pubmed-meshheading:17673218-Protein Kinase C,
pubmed-meshheading:17673218-Protein-Lysine 6-Oxidase,
pubmed-meshheading:17673218-Rats,
pubmed-meshheading:17673218-Receptors, Tumor Necrosis Factor, Type I,
pubmed-meshheading:17673218-Receptors, Tumor Necrosis Factor, Type II,
pubmed-meshheading:17673218-Sus scrofa,
pubmed-meshheading:17673218-Tumor Necrosis Factor-alpha,
pubmed-meshheading:17673218-Umbilical Veins
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pubmed:year |
2008
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pubmed:articleTitle |
Lysyl oxidase (LOX) down-regulation by TNFalpha: a new mechanism underlying TNFalpha-induced endothelial dysfunction.
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pubmed:affiliation |
Centro de Investigación Cardiovascular, CSIC-ICCC, Hospital de Santa Creu i Sant Pau, Barcelona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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