Linked Life Data

17668005

Source:http://linkedlifedata.com/resource/pubmed/id/17668005

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2007-8-1
pubmed:abstractText
gamma-Secretase is involved in the production of amyloid beta-peptide, which is the principal component of amyloid plaques in the brains of patients with Alzheimer disease. gamma-Secretase is a complex composed of presenilin (PS), nicastrin, anterior pharynx-defective phenotype 1 (Aph1) and PS enhancer 2 (Pen2). We previously proposed a mechanism of complex assembly by which unassembled subunits are retained in the endoplasmic reticulum (ER) and only the fully assembled complex is exported from the ER. We have now identified Retention in endoplasmic reticulum 1 (Rer1) as a protein that is involved in the retention/retrieval of unassembled Pen2 to the ER. Direct binding of unassembled Pen2 to Rer1 is mediated by the first transmembrane domain of Pen2, and a conserved asparagine in this domain is required. Downregulation of Rer1 leads to increased surface localization of Pen2, whereas overexpression of Rer1 stabilizes unassembled Pen2. To our knowledge, Rer1 is the first identified interaction partner of mammalian transmembrane-based retention/retrieval signals.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-10197533, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-12147673, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-12660785, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-12740439, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-12972550, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-1465129, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-14724271, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-14749724, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-15035625, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-15039426, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-15456788, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-15549135, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-15591316, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-17047368, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-17325205, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-1878135, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-1915263, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-8070399, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-8253791, http://linkedlifedata.com/resource/pubmed/commentcorrection/17668005-9309388
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1469-221X
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
743-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1.
pubmed:affiliation
Laboratory for Alzheimer's and Parkinson's Disease Research, Department of Biochemistry, Center For Integrated Protein Science Munich and Adolf-Butenandt-Institute, Ludwig-Maximilians-Universität, München 80336, Germany. ckaether@fli-leibniz.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't