| pubmed-article:17655212 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17655212 | lifeskim:mentions | umls-concept:C0268563 | lld:lifeskim |
| pubmed-article:17655212 | lifeskim:mentions | umls-concept:C1516769 | lld:lifeskim |
| pubmed-article:17655212 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:17655212 | lifeskim:mentions | umls-concept:C1880157 | lld:lifeskim |
| pubmed-article:17655212 | lifeskim:mentions | umls-concept:C0205231 | lld:lifeskim |
| pubmed-article:17655212 | lifeskim:mentions | umls-concept:C1611588 | lld:lifeskim |
| pubmed-article:17655212 | lifeskim:mentions | umls-concept:C1259444 | lld:lifeskim |
| pubmed-article:17655212 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:17655212 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:17655212 | pubmed:dateCreated | 2007-8-16 | lld:pubmed |
| pubmed-article:17655212 | pubmed:abstractText | AP2238 was the first compound published to bind both anionic sites of the human acetylcholinesterase, allowing the simultaneous inhibition of the catalytic and the amyloid-beta pro-aggregating activities of AChE. Here we attempted to derive a comprehensive structure-activity relationship picture for this molecule, affording 28 derivatives for which AChE and BChE inhibitory activities were evaluated. Selected compounds were also tested for their ability to prevent the AChE-induced Abeta-aggregation. Moreover, docking simulations and molecular orbital calculations were performed. | lld:pubmed |
| pubmed-article:17655212 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17655212 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17655212 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17655212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17655212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17655212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17655212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17655212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17655212 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17655212 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17655212 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:17655212 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:17655212 | pubmed:author | pubmed-author:CavalliAndrea... | lld:pubmed |
| pubmed-article:17655212 | pubmed:author | pubmed-author:RecanatiniMau... | lld:pubmed |
| pubmed-article:17655212 | pubmed:author | pubmed-author:BartoliniManu... | lld:pubmed |
| pubmed-article:17655212 | pubmed:author | pubmed-author:GobbiSilviaS | lld:pubmed |
| pubmed-article:17655212 | pubmed:author | pubmed-author:RampaAngelaA | lld:pubmed |
| pubmed-article:17655212 | pubmed:author | pubmed-author:BisiAlessandr... | lld:pubmed |
| pubmed-article:17655212 | pubmed:author | pubmed-author:BellutiFederi... | lld:pubmed |
| pubmed-article:17655212 | pubmed:author | pubmed-author:AndrisanoVinc... | lld:pubmed |
| pubmed-article:17655212 | pubmed:author | pubmed-author:PiazziLornaL | lld:pubmed |
| pubmed-article:17655212 | pubmed:author | pubmed-author:RizzoStefanoS | lld:pubmed |
| pubmed-article:17655212 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17655212 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:17655212 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:17655212 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17655212 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17655212 | pubmed:pagination | 4250-4 | lld:pubmed |
| pubmed-article:17655212 | pubmed:meshHeading | pubmed-meshheading:17655212... | lld:pubmed |
| pubmed-article:17655212 | pubmed:meshHeading | pubmed-meshheading:17655212... | lld:pubmed |
| pubmed-article:17655212 | pubmed:meshHeading | pubmed-meshheading:17655212... | lld:pubmed |
| pubmed-article:17655212 | pubmed:meshHeading | pubmed-meshheading:17655212... | lld:pubmed |
| pubmed-article:17655212 | pubmed:meshHeading | pubmed-meshheading:17655212... | lld:pubmed |
| pubmed-article:17655212 | pubmed:meshHeading | pubmed-meshheading:17655212... | lld:pubmed |
| pubmed-article:17655212 | pubmed:meshHeading | pubmed-meshheading:17655212... | lld:pubmed |
| pubmed-article:17655212 | pubmed:meshHeading | pubmed-meshheading:17655212... | lld:pubmed |
| pubmed-article:17655212 | pubmed:meshHeading | pubmed-meshheading:17655212... | lld:pubmed |
| pubmed-article:17655212 | pubmed:meshHeading | pubmed-meshheading:17655212... | lld:pubmed |
| pubmed-article:17655212 | pubmed:meshHeading | pubmed-meshheading:17655212... | lld:pubmed |
| pubmed-article:17655212 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17655212 | pubmed:articleTitle | Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives. | lld:pubmed |
| pubmed-article:17655212 | pubmed:affiliation | Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy. lorna.piazzi@unibo.it | lld:pubmed |
| pubmed-article:17655212 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17655212 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17655212 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17655212 | lld:pubmed |
