17652497

Source:http://linkedlifedata.com/resource/pubmed/id/17652497

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0010674, umls-concept:C0040405, umls-concept:C0205369, umls-concept:C1552081
pubmed:issue	4
pubmed:dateCreated	2007-7-26
pubmed:abstractText	This article presents a review and discussion of the current knowledge regarding cystic fibrosis (CF)-specific scoring of chest computed tomography (CT) scans. First, the basic principles of CT scoring systems in CF are described. Second, between- and within-observer variability of a composite CT score and of component CT scores are reviewed, and issues regarding training of CT scan readers discussed. Third, arguments regarding whether CT scoring systems are ready to be used in clinical studies as a surrogate endpoint are summarized. The between- and within-observer variability of the present CT composite scoring systems is low enough to be useful for clinical studies, although the variability for some of the component scores is larger than for others. Scoring systems fulfill the requirements for surrogate endpoints for CF lung disease, but this role could be further strengthened by including CT scans in large trials and demonstrating the correlation with true endpoints. The conclusion presented is that, given the experience of the variety of published scoring systems, it is important to develop a consensus CT scoring system for future studies in CF. Such a scoring system should evaluate all lung lobes individually and include all relevant CT findings in CF. Development of reference images for the components of this system will be important in reducing the variability between observers and to train new readers.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101203596
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	1546-3222
pubmed:author	pubmed-author:TiddensHarm A W MHA, pubmed-author:de JongPim APA
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	4
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	338-42
pubmed:meshHeading	pubmed-meshheading:17652497-Cystic Fibrosis, pubmed-meshheading:17652497-Humans, pubmed-meshheading:17652497-Lung, pubmed-meshheading:17652497-Observer Variation, pubmed-meshheading:17652497-Tomography, X-Ray Computed
pubmed:year	2007
pubmed:articleTitle	Cystic fibrosis specific computed tomography scoring.
pubmed:affiliation	Department of Pediatric Pulmonology and Allergology, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands. pimdejong@gmail.com
pubmed:publicationType	Journal Article, Review