Linked Life Data

17651958

Source:http://linkedlifedata.com/resource/pubmed/id/17651958

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-4-15
pubmed:abstractText
Epidemiological studies have demonstrated that people who eat more fruits and vegetables (rich in carotenoids) and people who have higher serum beta-carotene (BC) levels have a lower risk of cancer, particularly lung cancer. However, the two main human intervention studies of BC supplementation (the ATBC and the CARET trials) revealed an increased risk of lung cancer among smokers and asbestos workers. Previous studies carried out in the ferret have reported that BC effects are related to dose. Here, we treated ferrets with two concentrations of oral BC (0.8 and 3.2 mg/kg body weight per day) for 6 months, using BC in a formulation also containing dl-alpha-tocopherol and ascorbyl palmitate. The effect of the smoke-derived carcinogenic agent benzo[a]pyrene (BP), with or without low-dose BC, was also analysed. We determined the protein levels and mRNA expression levels of activator protein 1 (c-Jun and c-Fos), c-Myc, cyclin D1, proliferating cellular nuclear antigen and retinoic acid receptor beta. We did not find higher levels of cell proliferation markers in the lung of ferrets treated with BC or signals of squamous metaplasia lesions either. On the other hand, although no evident signals of pulmonary carcinogenesis were observed in animals exposed to BP, BC supplementation in these animals may prevent against excess cell proliferation, since this reestablishes Jun protein and cyclin D1 mRNA levels in the lung of BP-exposed animals. In summary, these results show that the combination of BC with alpha-tocopherol and ascorbyl palmitate does not induce pro-oxidant effects in the lung of ferrets.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0955-2863
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
295-304
pubmed:meshHeading
pubmed-meshheading:17651958-Animals, pubmed-meshheading:17651958-Ascorbic Acid, pubmed-meshheading:17651958-Benzo(a)pyrene, pubmed-meshheading:17651958-Biological Markers, pubmed-meshheading:17651958-Cell Cycle, pubmed-meshheading:17651958-Dietary Supplements, pubmed-meshheading:17651958-Female, pubmed-meshheading:17651958-Ferrets, pubmed-meshheading:17651958-Gene Expression Regulation, pubmed-meshheading:17651958-Lung, pubmed-meshheading:17651958-Mutagens, pubmed-meshheading:17651958-Proto-Oncogene Proteins c-fos, pubmed-meshheading:17651958-Proto-Oncogene Proteins c-jun, pubmed-meshheading:17651958-RNA, Messenger, pubmed-meshheading:17651958-Random Allocation, pubmed-meshheading:17651958-Time Factors, pubmed-meshheading:17651958-alpha-Tocopherol, pubmed-meshheading:17651958-beta Carotene
pubmed:year
2008
pubmed:articleTitle
Effects of 6-month daily supplementation with oral beta-carotene in combination or not with benzo[a]pyrene on cell-cycle markers in the lung of ferrets.
pubmed:affiliation
Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Palma de Mallorca and CIBER Fisiopatología obesidad y nutrición (CB06/03) Instituto Salud Carlos III, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't