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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2007-10-12
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pubmed:abstractText |
We report three novel inhibitors of the physiological pyrophosphatase activity of alkaline phosphatase and show that these compounds are capable of reducing calcification in two models of vascular calcification (i.e., they suppress in vitro calcification by cultured Enpp1(-/-) VSMCs and they inhibit the increased pyrophosphatase activity in a rat aortic model).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0884-0431
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1700-10
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pubmed:meshHeading |
pubmed-meshheading:17638573-Alkaline Phosphatase,
pubmed-meshheading:17638573-Animals,
pubmed-meshheading:17638573-Aortic Diseases,
pubmed-meshheading:17638573-Binding Sites,
pubmed-meshheading:17638573-Calcinosis,
pubmed-meshheading:17638573-Cells, Cultured,
pubmed-meshheading:17638573-Enzyme Inhibitors,
pubmed-meshheading:17638573-Humans,
pubmed-meshheading:17638573-Imidazoles,
pubmed-meshheading:17638573-Mice,
pubmed-meshheading:17638573-Mice, Mutant Strains,
pubmed-meshheading:17638573-Muscle, Smooth, Vascular,
pubmed-meshheading:17638573-Myocytes, Smooth Muscle,
pubmed-meshheading:17638573-Osteoarthritis,
pubmed-meshheading:17638573-Phosphoric Diester Hydrolases,
pubmed-meshheading:17638573-Pyrophosphatases,
pubmed-meshheading:17638573-Triazines,
pubmed-meshheading:17638573-Triazoles
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pubmed:year |
2007
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pubmed:articleTitle |
Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification.
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pubmed:affiliation |
The Burnham Institute, La Jolla, California, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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